Detection and treatment of cancers of the breast
AssigneeThe Regents of the University of Michigan
InventorsSamir M. Hanash, Francois LeNaour, David Misek, Melissa Krause
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Abstract
The present invention relates to compositions and methods for cancer therapies and diagnostics, including but not limited to, cancer markers. In particular, the present invention provides tumor antigens associated with specific cancers and diagnostic assays for the detection of such antigens and associated autoantibodies as indicative of the presence of specific cancers. The present invention further provides cancer immunotherapy utilizing the tumor antigens of the present invention.
Claims30
A method for detecting cancer, comprising:
- a) providing a sample from a subject suspected of having cancer;
- and
- b) detecting the presence of a tumor antigen in said sample, thereby detecting cancer.
A kit for detecting the presence of cancer in a subject, comprising:
- a) a reagent capable of specifically detecting the presence of a tumor antigen;
- and
- b) instructions for using said reagent for detecting the presence of cancer in said subject.
A method for eliciting a cancer specific immune response, comprising:
- a) providing
- i) an immunogenic composition comprising a tumor antigen;
- and
- ii) a subject diagnosed with a cancer;
- and
- b) administering said immunogenic composition to said subject under conditions that said subject generates an immune response to said cancer.
A method of treating cancer in a subject, comprising:
- a) providing
- i) a subject;
- and
- ii) a therapeutic composition comprising an antibody directed toward a tumor antigen;
- and
- b) administering said therapeutic composition to said subject.
Dependencies are inferred from the claim text.