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US 2003/0119077 A1Published application
Method of enriching rare cells
AssigneeJohn Hopkins University School of Medicine
InventorsPaul O. P. Ts'o, Zheng-Pin Wang, Stephen A. Lesko, William G. Nelson, Alan W. Partin
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Abstract
The present invention provides for enriching rare cells in a fluid comprising the rare cells and non-rare cells. Examples of rare cells enriched include prostate cancer cells.
Claims14
A method for enriching rare cells of interest in a bodily fluid sample comprising rare cells and non-rare cells, comprising:
- (a) obtaining a bodily fluid sample comprising rare cells of interest and non-rare cells;
- (b) subjecting said sample to a binding agent that binds non-rare cells;
- (c) removing the bound non-rare cells from the sample so as to provide a sample enriched with the rare cells of interest.
A method for enriching rare cells of interest in a bodily fluid sample comprising rare cells and non-rare cells, comprising:
- (a) obtaining a bodily fluid sample comprising rare cells of interest and non-rare cells;
- (b) subjecting said sample to density gradient separation;
- (c) selecting at least one gradient of interest and subjecting said gradient of interest to a binding agent that binds non-rare cells;
- (d) removing the bound non-rare cells from the gradient of interest so as to provide a sample enriched with the rare cells of interest.
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Dependencies are inferred from the claim text.