Diagnosis and treatment of dementia utilizing thrombospondin
OwnerGeorge Jackowski, Rulin Zhanginventors
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Abstract
A method for diagnosing various forms of dementia, including MCI, and Alzheimer's disease(AD) is disclosed. The method involves directly detecting the presence of a biochemical marker, specifically thrombospondin, in bodily fluid, preferably blood or a blood product. The detection is by an immunoassay incorporating an antibody specific to thrombospondin, or alternatively an autoantibody to a thrombospondin antibody.
Claims14
A method for diagnosing dementia in a mammal comprising:
- obtaining a sample of body fluid from said mammal;
- contacting said sample with at least one antibody which specifically binds to a marker indicative of thrombospondin;
- determining a presence of thrombospondin in said sample;
- and
- correlating the presence of thrombospondin with the occurrence of dementia.
A diagnostic kit for diagnosing and monitoring the progression of dementia comprising:
- at least one antibody which is specific for a marker indicative of thrombospondin, said antibody or marker capable of being immobilized on a solid support;
- and at least one labeled antibody, which binds to said marker;
- whereby at least one analysis to determine a presence of a marker, an antibody specific thereto, or their immunologically detectable fragments, is carried out on a sample of a body fluid.
A process for the determination of dementia according to the principle of immunoassay, characterized in that a serum or plasma sample with at least one antibody against thrombospondin and a binding partner for thrombospondin or for the antibody is incubated, whereby either the antibody against thrombospondin or the binding partner is labeled with a determinable group, the thereby formed immunological complex which contains the determinable group is separated off and the determinable group in the separated off or still remaining phase is determined as measure for thrombospondin from the sample.
A process according to 10 characterized in that the sample with an antibody against thrombospondin and a conjugate of thrombospondin and a determinable group is incubated, the formed immunological complex is separated off by phase separation and the determinable group is determined in one of the phases.
Use of antibodies against thrombospondin for the determination of dementia.
Use of autoantibodies against thrombospondin antibodies for the determination of dementia.
Dependencies are inferred from the claim text.