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AssigneeThe Trustees of Columbia University in the City of New York
InventorsW. Clark Still, Michael H.J. Ohlmeyer, Lawrence W. Dillard, John C. Reader, Michael H. Wigler
Estimating the term…
Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and synthetic non-repetitive organic molecules. Conveniently, nested families of compounds can be employed as identifiers, where number and/or position of a substituent define the choice. Alternatively, detectable functionalities may be employed, such as radioisotopes, fluorescers, halogens, and the like, where presence and ratios of two different groups can be used to define stage or choice. Particularly, pluralities of identifiers may be used to provide a binary or higher code, so as to define a plurality of choices with only a few detachable tags. The particles may be screened for a characteristic of interest, particularly binding affinity, where the products may be detached from the particle or retained on the particle. The reaction history of the particles which are positive for the characteristic can be determined by the release of the tags and analysis to define the reaction history of the particle.
A method for recording the reaction history of a reaction series on each of a plurality of unique solid supports, wherein said reaction series involves at least two stages requiring differing agents or reaction conditions resulting in a different modification as to a plurality of said unique solid supports, resulting in a plurality of different final products on different unique solid supports, employing a combination of identifiers for recording said reaction history, said identifiers characterized by defining the choice of agent or reaction condition and the stage in said reaction series and being capable of being analyzed as to the choice and stage, said method comprising:
A kit comprising a plurality of different separated organic compounds, each of the compounds characterized by having a distinguishable composition, encoding at least one bit of different information which can be determined by a physical measurement and sharing at least one common functionality.
A solid support characterized by having a ligand bound thereto and having a combination of identifiers bound to said solid support.
A method for producing a ligand involving a reaction series employing a method for recording the reaction history of a reaction series on each of a plurality of unique solid supports, wherein said reaction series involves at least two stages requiring differing agents and/or reaction conditions resulting in a different modification as to a plurality of said unique solid supports, resulting in a plurality of different final products on different unique solid supports, employing a combination of identifiers for recording said reaction history, said identifiers characterized by defining the choice of agent or reaction condition and the stage in said series and being capable of being analyzed as to the choice and stage, said method comprising:
A method for producing a ligand involving a reaction series employing a method for recording the reaction history of a reaction series on each of a plurality of unique solid surfaces, wherein said reaction series involves at least two stages requiring differing agents and/or reaction conditions resulting in a different modification as to each of a plurality of said unique solid surfaces, resulting in a plurality of different ligands on different unique solid surfaces, employing combinations of identifiers for recording said reaction history, said combination of identifiers characterized by defining the choice of agent and/or reaction condition and the stage in said series and being capable of being analyzed as to the choice and stage, said method comprising:
A compound of the Formula I:
A composition of the formula
A compound of the formula
A method of synthesizing a chemical compound so that the structure of the compound is readily determinable, which comprises synthesizing the compound on the surface of a solid support under conditions such that the solid support at the completion of the synthesis of the compound has bound to it a plurality of identifiers which encode the reaction stages associated with the synthesis of the compound.
A method of synthesizing a library of chemical compounds so that the structure of each compound in the library is readily determinable which comprises synthesizing each compound on the surface of a unique solid support under conditions such that each such unique support at the completion of the synthesis of the library of compounds has bound to it a plurality of identifiers which encode the reaction stages associated with the synthesis of the compound synthesized on such solid support.
A library of chemical compounds, each compound in the library being bound to a unique solid support and each such solid support having bound to it a plurality of identifiers which encode the reaction stages associated with the synthesis of the compound bound to such solid support.
A composition comprising at least 6 different components, said components being associated in a kit or in a common medium, each component having a distinguishable moiety, said components being characterized by:
A composition comprising at least 6 different markers said markers being associated in a kit or in a common medium, each marker having a distinguishable moiety which is substantially chemically inert, differing from each other in molecular weight, said markers of the formula:
A compound library comprising at least one hundred unique solid supports characterized by:
Dependencies are inferred from the claim text.