Cancer-associated genes
AssigneeTakara Shuzo Co., Ltd.
InventorsYoshie Yoshikawa, Hiroyuki Mukai, Kiyozo Asada, Fumitsugu Hino, Ikunoshin Kato
Life of this patent
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Abstract
To provide a method for detecting a cancer cell in a resected specimen by determining a change in an expression level of at least one of cancer-associated genes selected from genes of which cDNA is a DNA comprising a nucleotide sequence as shown in any one of SEQ ID NOs: 1 to 16 and 66 to 68 in Sequence Listing, or a DNA capable of hybridizing with a nucleic acid consisting of a nucleotide sequence as shown in any one of SEQ ID NOs: 1 to 16 and 66 to 68 in Sequence Listing under stringent conditions; as well as a kit for detecting cancer by the above method, and the like.
Claims15
A method for detecting a cancer cell in a resected specimen, characterized by determining a change in an expression level of at least one of cancer-associated genes selected from genes of which cDNA is a DNA comprising a nucleotide sequence as shown in any one of SEQ ID NOs:
- 1 to 16 and 66 to 68 in Sequence Listing, or a DNA capable of hybridizing with a nucleic acid consisting of a nucleotide sequence as shown in any one of SEQ ID NOs:
- 1 to 16 and 66 to 68 in Sequence Listing under stringent conditions.
A method for controlling proliferation of a cancer cell using a substance specifically binding to a gene or an expression product of said gene, characterized in that cDNA of the gene is at least one of DNAs selected from a DNA comprising a nucleotide sequence as shown in any one of SEQ ID NOs:
- 1 to 16 and 66 to 68 in Sequence Listing, or a DNA capable of hybridizing with a nucleic acid consisting of any one of these nucleotide sequences under stringent conditions, wherein the DNA is usable for detection of a cancer cell by a change in an expression level thereof.
A peptide usable for detection of a cancer cell, characterized in that the peptide is shown in an amino acid sequence comprising an entire portion of any one of amino acid sequences as shown in SEQ ID NOs:
- 17 to 19, 69 and 70 in Sequence Listing or a partial portion thereof.
A peptide usable for detection of a cancer cell, characterized in that the peptide has an amino acid sequence comprising an amino acid sequence resulting from at least one of deletion, substitution or addition of one or more amino acid residues in an amino acid sequences as shown in any one of SEQ ID NOs:
- 17 to 19, 69 and 70 in Sequence Listing.
A kit for detecting a gastric cancer cell, wherein the kit comprises primer pairs which are capable of amplifying a mRNA for a cancer-associated gene to be detected of which change in an expression level is to be determined, wherein said cancer-associated gene consists of the nucleotide sequence selected from the group consisting of SEQ ID NOs:
- 1 and 66, and wherein the primer pairs consist of at least two primers, each comprising 10 to 30 nucleotides.
Dependencies are inferred from the claim text.