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AssigneeBiomerieux
InventorsJaap Michiel Middeldorp, Johannes Martinus Gerardus Van De Crommert
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The invention relates to a peptide reagent comprising peptides immunochemically reactive with antibodies to the human cytomegalovirus (CMV). New antibodies directed to said peptides or fragments thereof are also part of the invention. Also cell lines capable of producing monoclonal antibodies are part of the invention. The invention also relates to a method for the detection of CMV or antibodies directed against CMV in a test fluid and a test kit to be used when applying the said detection methods. Detection of CMV in a test fluid or tissue specimen using antibodies, monoclonal and polyclonal, directed to said peptide, which have the characteristics of detecting both native and denatured DMV proteins are also part of said invention.
Peptide reagent for the detection of antibodies to Cytomegalovirus, characterized in that said reagent comprises a peptide derived from Cytomegalovirus structural phosphoprotein pp150 (UL32) and one or more peptides derived from one of the Cytomegalovirus proteins;
Monoclonal antibody which binds to an epitope of a peptide having the amino acid sequence as shown in SEQ ID No.:
Monoclonal antibody which binds to an epitope of the CMV pp150-protein, which epitope is recognized by monoclonal antibody CMV.OT3C produced by the hybridoma cell lines deposited with the European Collection of Animal Cell Cultures (ECACC), CAMR (Centre for Applied Microbiology & Research), Salisbury (UK), under deposit No. 96071123.
Dependencies are inferred from the claim text.