Enzymatic nucleic acid treatment of diseases or conditions related to levels of IKK-gamma and PKR
AssigneeSirna Theraputics, Inc.
InventorJames A. McSwiggen
Life of this patent
Estimating the term…
Abstract
The present invention relates to nucleic acid molecules, including antisense and enzymatic nucleic acid molecules, such as hammerhead ribozymes, DNAzymes, allozymes, aptamers, decoys and siRNA (RNAi), which modulate the expression or function of IKK genes, such as IKK-gamma, IKK-alpha, or IKK-beta, and PKR genes.
Claims13
An enzymatic nucleic acid molecule which down regulates expression of a nucleic acid molecule encoding an IkappaB kinase (IKK) subunit.
An enzymatic nucleic acid molecule which down regulates expression of a nucleic acid molecule encoding protein kinase PKR.
An enzymatic nucleic acid molecule comprising a sequence selected from the group consisting of SEQ ID NOs:
- 632-1261, 1762-2260, 2480-2698, 2904-3485, 3814-4360, 4555-4748, 5253-5756, 6034-6310, 6380-6789, 7142-7770, and 7884-8001.
An enzymatic nucleic acid molecule comprising at least one binding arm wherein one or more of said binding arms comprises a sequence complementary to a sequence selected from the group consisting of SEQ ID NOs:
- 1-631, 1263-1761, 2261-2479, 2699-2903, 3486-3813, 4361-4554, 4749-5252, 5757-6033, 6311-6379, 6790-7141, and 7771-7883.
An antisense nucleic acid molecule comprising a sequence complementary to a sequence selected from the group consisting of SEQ ID NOs:
- 1-631, 1263-1761, 2261-2479, 2699-2903, 3486-3813, 4361-4554, 4749-5252, 5757-6033, 6311-6379, 6790-7141, and 7771-7883.
A nucleic acid molecule that down regulates expression of an IKK-gamma gene by RNA interference.
A nucleic acid molecule that down regulates expression of a PKR gene, by RNA interference.
Dependencies are inferred from the claim text.