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US 2003/0118980 A1Published application
System for organ and tissue preservation and hypothermic blood substitution
AssigneeOrgan Recovery Systems, Inc.
InventorMichael J. Taylor
Life of this patent
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Abstract
A unified solution system for organ and/or tissue preservation and/or hypothermic blood substitution can be used to prepare multiple solutions for use in various stages of organ procurement, preservation and transplantation and bloodless surgery procedures.
Claims73
A method of preserving an organ or tissue, comprising the steps of:
- (a) providing a base electrolyte solution;
- (b) mixing a first portion of the base solution with a first additive to produce a first mixed solution;
- (c) contacting the first mixed solution with an organ or tissue during at least one stage of procurement, preservation or transplantation of that organ or tissue;
- (d) mixing a second portion of the base solution with a second, different additive to produce a second, different mixed solution;
- and
- (e) contacting the second mixed solution with an organ or tissue during at least one stage of procurement, preservation or transplantation of that organ or tissue.
3 more elements
An organ or tissue preservation solution, comprising:
- 40-80 or 100-150 mM/l Na+;
- 15-40 or 50-90 mM/l K+;
- 0.01-0.1 mM/l Ca++;
- 5-25 mM/l Mg++;
- 20-40 mM/l Cl−;
- 1-5 mM/l H2PO4−;
- 3-7 mM/l HCO3−;
- 25-50 mM/l HEPES;
- 25-50 mM/l Lactobionate;
- 10 mM/l-1M/l Sucrose;
- 15-30 mM/l Mannitol;
- 1-10 mM/l Glucose;
- 50-100 mM/l Gluconate;
- 6% Dextran 40;
- 0.1-2 mM/l Adenosine;
- and optionally
- 1-5 mM/l Glutathione.
14 more elements
An organ or tissue preservation solution, comprising:
- about 62.5 or 125 mM/l Na+;
- about 25 or 70.0 mM/l K+;
- about 0.05 mM/l Ca++;
- about 15.0 mM/l Mg++;
- about 30.1 mM/l Cl−;
- about 2.5 mM/l H2PO4−;
- about 5.0 mM/l HCO3−;
- about 35.0 mM/l HEPES;
- about 30.0 mM/l Lactobionate;
- about 15.0 mM/l Sucrose;
- about 25.0 mM/l Mannitol;
- about 5.0 mM/l Glucose;
- about 70.0 mM/l Gluconate;
- about 6% Dextran 40;
- and
- about 2.0 mM/l Adenosine.
13 more elements
An organ or tissue preservation solution, comprising:
- 120-160 mM/l Na+;
- 3-9 mM/l K+;
- 1-3 mM/l Ca++;
- 1-10 mM/l Mg++;
- 100-150 mM/l Cl−;
- 1-10 mM/l SO4−;
- 1-3 mM/l H2PO4−;
- 20-30 mM/l HCO3−;
- 5-15 mM/l HEPES;
- 5-10 mM/l Glucose;
- 6% Dextran 40;
- 0.1-2 mM/l Adenosine;
- and optionally
- 1-5 mM/l Glutathione.
11 more elements
An organ or tissue preservation solution, comprising:
- about 141.2 mM/l Na+;
- about 6.0 mM/l K+;
- about 1.5 mM/l Ca++;
- about 5.0 mM/l Mg++;
- about 122.0 mM/l Cl−;
- about 1.0 mM/l SO4−;
- about 1.2 mM/l H2PO4−;
- about 25.0 mM/l HCO3−;
- about 25.0 mM/l HEPES;
- about 5.0 mM/l Glucose;
- about 6% mM/l Dextran 40;
- and
- about 1.0 mM/l Adenosine.
10 more elements
A solution kit comprising a saleable package containing:
- at least one first container containing at least one base electrolyte solution;
- and
- at least two second containers respectively containing different additives for converting said base solution to different mixed solutions for use in different stages of procurement, preservation or transplantation of an organ or tissue.
Dependencies are inferred from the claim text.