Taste masked aqueous liquid pharmaceutical composition

A liquid pharmaceutical composition comprising:

• 5 g acetaminophen, 0.3 g xanthan gum, 55 g sucrose, 10 g 70% sorbitol solution, 20 g invert sugar, 5 g glycerin, 2.5 to 5 g crospovidone, 0 to 2.5 g polyethylene glycol with an average molecular weight between 1000 to 4000, 0.2 g sodium benzoate, 0.05 g sorbitan monolaurate, 0.2 g edetate disodium, 0.2 g sucralose, 0.13 g saccharin sodium, 0 to 0.006 g FD&C or D&C color, 0.2 to 0.4 g flavor, water to a volume of 100 mL, citric acid-sodium citrate dihydrate to a pH of 5 to 6.

A liquid pharmaceutical composition comprising:

• 10 g acetaminophen, 0.3 g xanthan gum, 54 g sucrose, 10 g 70% sorbitol solution, 20 g invert sugar, 5 g glycerin, 5 to 10 g crospovidone, 0 to about 1 g polyethylene glycol with an average molecular weight between 1000 to 4000, 0.2 g sodium benzoate, 0.05 g sorbitan monolaurate, 0.2 g edetate disodium, 0.4 g sucralose, 0.26 g saccharin sodium, 0 to 0.006 g FD&C or D&C color, 0.2 to 0.4 g flavor, water to a volume of 100 mL, citric acid-sodium citrate dihydrate to a pH of 5 to 6.

A liquid pharmaceutical composition comprising:

• 2 to 4 g guaifenesin, 51 g sucrose, 30 g 70% sorbitol solution, 7.5 g glycerin, 2.5 g to 5 g povidone, 0 to 1.5 g polyethylene glycol with an average molecular weight between 1000 to 4000, 0.2 g sodium benzoate, 0.1 g sucralose, from about 0.2 to about 0.4 g flavor, water to a volume of 100 mL, citric acid to a pH of 3 to 4.

A liquid pharmaceutical composition comprising:

• 0.3 g dextromethorphan hydrobromide, 60 g sucrose, 20 g invert sugar, 2.5 g to 5 g povidone, from about 0 to 1 g polyethylene glycol with an average molecular weight between 1000 to 6000, 0.2 g sodium benzoate, 0.2 g sucralose. 0.13 g saccharin sodium, 0.2 to about 0.4 g flavor, water to a volume of 100 mL, citric acid-sodium citrate dihydrate to a pH of 4.5 to 5.5.

A liquid pharmaceutical composition comprising:

• 0.3 g diphenhydramine hydrochloride, 40 g 70% sorbitol solution, 30 g glycerin, 2.5 g to 5 g povidone, 0 to 2.25 g polyethylene glycol with an average molecular weight between 1000 to 8000, 0.2 g sodium benzoate, 0.2 g sucralose. 0.13 g saccharin sodium, 0.2 to 0.4 g flavor, water to a volume of 100 mL, citric acid-sodium citrate dihydrate to a pH of 4.5 to 5.5.

A liquid pharmaceutical composition comprising:

• 0.08 g brompheniramine maleate, 40 g 70% sorbitol solution, 30 g glycerin, 2.5 g to 5 g povidone, 0 to 2.25 g polyethylene glycol with an average molecular weight between 1000 to 8000, 0.2 g sodium benzoate, 0.2 g sucralose. 0.13 g saccharin sodium, 0.2 to 0.4 g flavor, water to a volume of 100 mL, citric acid-sodium citrate dihydrate to a pH of 3 to 4.

A ready-to-use powder or granules for reconstitution wherein after reconstitution to 100 mL with water, the liquid pharmaceutical composition comprises:

• 3.25 to 13 g amoxicillin trihydrate, 45 g sucrose, 0.06 g sorbitan monolaurate, 0.5 to 2.5 g povidone and/or copolyvidone, 0.1 to about 0.5 g polyethylene glycol with an average molecular weight between 1000 to 8000, 0.10 g methylparaben, 0.02 propylparaben, 0 to 0.004 g FD&C or D&C color, 0.20 to 1 g flavor, 1.2 g precipitated silica, and sodium citrate to pH 4-6.

A ready-to-use powder or granules for reconstitution wherein after recontitution to 100 mL with water, the liquid pharmaceutical composition comprises:

• 2 to 10 g cloxacillin sodium, 45 g sucrose, 0.06 g sorbitan monolaurate, 0.5 to 2.5 g povidone and/or copolyvidone, 0.1 to about 0.5 g polyethylene glycol with an average molecular weight between 1000 to 8000, 0.10 g methylparaben, 0.02 propylparaben, 0 to 0.004 g FD&C or D&C color, 0.20 to 1 g flavor, 1.2 g precipitated silica, and sodium citrate to pH 4-6.