Methods and compositions for use of (S)-bisoprolol

A composition comprising a therapeutically effective amount of enriched (S)-bisoprolol, or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipients.

A method of treating one or more cardiovascular conditions comprising administering a therapeutically effective amount of enriched (S)-bisoprolol, or a pharmaceutically acceptable salt thereof, to a subject in need of such a treatment, wherein the subject obtains a therapeutic benefit resulting from the administration of enriched (S)-bisoprolol, and wherein the amount of enriched (S)-bisoprolol, or pharmaceutically acceptable salt thereof, is less than the amount of racemic bisoprolol required to achieve the same therapeutic benefit.

A method of reducing one or more side effects associated with racemic bisoprolol comprising administering a therapeutically effective amount of enriched (S)-bisoprolol, or a pharmaceutically acceptable salt thereof, to a subject in need of such a reduction, wherein one or more side-effects are reduced relative to those resulting from the administration of an equivalent amount of racemic bisoprolol.

A method of reducing one or more drug interactions associated with administration of racemic bisoprolol comprising administering a therapeutically effective amount of enriched (S)-bisoprolol, or a pharmaceutically acceptable salt thereof, to a subject in need of such a reduction, wherein one or more drug interactions are reduced relative to those resulting from the administration of an equivalent amount of racemic bisoprolol.

A method of reducing oxidative metabolism by the cytochrome P450 isoform CYP2D6 associated with racemic bisoprolol comprising administering a therapeutically effective amount of enriched (S)-bisoprolol, or a pharmaceutically acceptable salt thereof, to a subject in need of such a reduction, wherein the amount of oxidative metabolism by the cytochrome P450 isoform CYP2D6 in the subject is reduced relative to the amount of oxidative metabolism by the cytochrome P450 isoform CYP2D6 in a subject receiving an equivalent amount of racemic bisoprolol.

A method of preventing one or more cardiovascular conditions treatable with racemic bisoprolol, comprising administering a therapeutically effective amount of enriched (S)-bisoprolol, or a pharmaceutically acceptable salt thereof, to a subject in need of such prevention, wherein the administration of enriched (S)-bisoprolol, or pharmaceutically acceptable salt thereof, reduces one or more side-effects relative to a racemic mixture of bisoprolol.

A method of managing one or more cardiovascular conditions comprising administering a therapeutically effective amount of enriched (S)-bisoprolol, or a pharmaceutically acceptable salt thereof, to a subject in need of such management, wherein the administration of enriched (S)-bisoprolol, or pharmaceutically acceptable salt thereof, reduces one or more side-effects relative to a racemic mixture of bisoprolol.

A method of extending the therapeutic effect of a treatment for one or more cardiovascular conditions comprising administering a therapeutically effective amount of enriched (S)-bisoprolol, or a pharmaceutically acceptable salt thereof, to a subject in need of such treatment, wherein the administration of enriched (S)-bisoprolol, or pharmaceutically acceptable salt thereof, provides a therapeutic effect that lasts longer than the therapeutic effect achieved by administration of an equal amount of racemic bisoprolol.

A method of reducing the variability in metabolism of racemic bisoprolol associated with polymorphic expression of cytochrome P450 isoform CYP2D6, comprising administering a therapeutically effective amount of enriched (S)-bisoprolol, or a pharmaceutically acceptable salt thereof, to a subject in need of such a reduction, wherein the variability in metabolism by cytochrome P450 isoform CYP2D6 in the subject is reduced relative to the variability in metabolism by the cytochrome P450 isoform CYP2D6 in a subject receiving an equivalent amount of racemic bisoprolol.

A method of reducing the effects of inducers or inhibitors of cytochrome P450 isoform CYP2D6 comprising administering a therapeutically effective amount of enriched (S)-bisoprolol, or a pharmaceutically acceptable salt thereof, to a subject in need of such a reduction, wherein the effects of inducers or inhibitors of cytochrome P450 isoform CYP2D6 in the subject is reduced relative to the effects of inducers or inhibitors of cytochrome P450 isoform CYP2D6 in a subject receiving an equivalent amount of racemic bisoprolol.