Drug delivery devices and methods
OwnerJinming Gao, Feng Qian +2inventors
InventorsJinming Gao, Feng Qian, Agata Exner, John R. Haaga
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Abstract
The present invention relates to drug delivery devices that provide sustained release of a therapeutic agent upon implantation into a patient. In certain embodiments, the devices provide an initial burst release of an agent, followed by sustained release of that agent, or of a different agent. The devices comprise a central core surrounded at least one membrane or coating.
Claims39
A biodegradable dual-release drug delivery device, comprising:
- a) a central core comprising a first bioactive agent, and
- b) a first layer disposed around the central core comprising a second bioactive agent and a biodegradable polymer,
- whereby, upon placement in a biological environment, the second bioactive agent is released, thereby resulting in sustained release of the first bioactive agent.
A biodegradable drug delivery device, comprising:
- a) a central core comprising a first bioactive agent,
- b) a first layer disposed around the central core, comprising a water-soluble component and a biodegradable polymer, and
- c) a water-soluble second layer comprising a second bioactive agent disposed around the first layer,
- whereby, upon placement in a biological environment, the second bioactive agent is released and the water-soluble component dissolves rendering the first layer porous, thereby resulting in sustained release of the first bioactive agent.
The device of claim 33, wherein the first bioactive agent is released at a therapeutically effective concentration for at least a week.
A method for manufacturing a biodegradable drug delivery device, comprising:
- a) providing a central core comprising a first bioactive agent, and
- b) disposing a layer around the central core, the layer comprising a second bioactive agent, a water-soluble component, and a biodegradable polymer.
A method for manufacturing a biodegradable drug delivery device, comprising:
- a) providing a central core comprising a first bioactive agent and an excipient,
- b) disposing around the central core a first layer comprising a water-soluble component and a biodegradable polymer, and
- c) disposing around the first layer a water-soluble second layer comprising a second bioactive agent.
Dependencies are inferred from the claim text.