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US 2003/0118647 A1Published application
Extended release tablet of metformin
OwnerPawan Sethinventor
Life of this patent
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Abstract
The invention provides an extended release tablet, comprising: (i) a core comprising metformin; and (ii) a coating consisting essentially of a water-insoluble, water-permeable film-forming polymer, a plasticizer and a water-soluble polymer.
Claims46
An extended release tablet comprising:
- (i) a core comprising by weight, based on the core weight, 70 to 99% of metformin, and conventional excipients;
- and
- (ii) a coating consisting essentially by weight, based on the coating weight, of 20 to 85% of a water-insoluble, water-permeable film-forming polymer, of 10 to 75% of a water-soluble polymer and 3 to 40% of a plasticizer,
- exhibiting a dissolution profile such that after 2 hours, from 7 to 60% of the metformin is released;
- after 4 hours, from 15 to 90% of the metformin is released;
- after 8 hours, from 50 to 100% of the metformin is released;
- after 12 hours, more than 75% of the metformin is released.
4 more elements
An extended release tablet comprising:
- (i) a core comprising by weight, based on the core weight, 70 to 99% of metformin, and conventional excipients;
- and
- (ii) a coating consisting essentially by weight, based on the coating weight, of 50 to 85% of a water-insoluble, water-permeable film-forming polymer, of 10 to 35% of a water-soluble polymer and 3 to 15% of a plasticizer;
- exhibiting a dissolution profile such that after 2 hours, from 7 to 60% of the metformin is released;
- after 4 hours, from 15 to 90% of the metformin is released;
- after 8 hours, from 50 to 100% of the metformin is released;
- after 12 hours, more than 75% of the metformin is released.
4 more elements
An extended release tablet comprising:
- (i) a core comprising by weight, based on the core weight, 70 to 99% of metformin, an expanding agent and conventional excipients;
- and
- (ii) a coating consisting essentially by weight, based on the coating weight, of 20 to 50% of a water-insoluble, water-permeable film-forming polymer, of 35 to 75% of a water-soluble polymer and 15 to 40% of a plasticizer;
- exhibiting a dissolution profile such that after 2 hours, from 7 to 60% of the metformin is released;
- after 4 hours, from 15 to 90% of the metformin is released;
- after 8 hours, from 50 to 100% of the metformin is released;
- after 12 hours, more than 75% of the metformin is released.
4 more elements
Dependencies are inferred from the claim text.