Pharmaceutical compositions for rectal and vaginal administration
OwnerS. Indiran Pather, Joseph R. Robinson +3inventors
InventorsS. Indiran Pather, Joseph R. Robinson, Jonathan D. Eichman, Rajendra K. Khankari, John Hontz
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Abstract
The pharmaceutical compositions of the present invention comprise rectally and vaginally administerable dosage forms that contain effervescent agents as penetration enhancers for drugs. Effervescence occurs in the rectum or vagina, once the dosage form is administered or at a predetermined time following administration. The effervescent agents can be used alone or in combination with pH adjusting substance, which further promote dissolution and absorption of the active ingredient.
Claims28
A dosage form adapted for rectal administration of a therapeutically effective amount of an active ingredient to a target area in the rectum of a mammal;
- comprising:
- (a) a therapeutically effective amount of an active ingredient;
- and
- (b) at least one effervescent penetration enhancer;
- wherein said at least one effervescent penetration enhancer is present in an amount sufficient to increase the penetration of said active ingredient across said target area of said rectum, and to permit delivery of a therapeutically effective amount of said active ingredient.
A method for delivering an active ingredient to a target area in the rectum of a mammal;
- comprising the steps of:
- (a) administering in the rectum of a mammal a dosage form comprising a therapeutically effective amount of an active ingredient and at least one effervescent penetration enhancer present in an amount sufficient to increase absorption of said active ingredient across a mucosa layer of said target area,
- (b) causing said active ingredient and said effervescent penetration enhancer to release from said dosage form at said target area in said rectum and to provide effervescent action at said target area;
- so that said effervescent action promotes the absorption of a therapeutically effective amount of said active ingredient across said target area.
A dosage form adapted for vaginal administration of a therapeutically effective amount of an active ingredient to a target area in the vagina of a mammal;
- comprising:
- (a) a therapeutically effective amount of an active ingredient;
- and
- (b) at least one effervescent penetration enhancer;
- wherein said at least one effervescent penetration enhancer is present in an amount sufficient to increases the penetration of said active ingredient across said target area of said vagina.
A method for delivering an active ingredient to a target area in the vagina of a mammal;
- comprising the steps of:
- (a) administering in the vagina of a mammal a dosage form comprising a therapeutically effective amount of an active ingredient and at least one effervescent penetration enhancer present in an amount sufficient to increase absorption of said active ingredient across a mucosa layer of said target area,
- (b) causing said active ingredient and said effervescent penetration enhancer to release from said dosage form at said target area in said vagina and to provide effervescent action at said target area;
- so that said effervescent action promotes the absorption of a therapeutically effective amount of said active ingredient across said target area.
Dependencies are inferred from the claim text.