Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms
AssigneeSPI Pharma, Inc.
InventorsGary Telfer Norman, Kalyan S. Nuguru, Arun F. Amin, Sarath Chandar
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Abstract
The present invention comprises a co-processed carbohydrate system, and formulations produced therefrom, which formulations are directly compressible into solid dosage forms, some of which rapidly and completely dissolve or disintegrate in the oral cavity within 60 seconds. The invention also comprises the solid dosage forms produced by directly compressing the co-processed carbohydrate system, some of which, when placed in the oral cavity, shall dissolve or disintegrate, preferably within about 60 seconds.
Claims55
A method for producing a directly compressible and highly compactible composition, said method comprising:
- a) dissolving mannitol powder and sorbitol powder into a solution;
- b) drying the solution in an air stream, and
- c) forming particles having a nonfilamentous microstructure from the solution.
A quick-dissolving composition comprising co-spray-dried mannitol and sorbitol, and a disintegrant, wherein said composition is highly compactible and dissolves in the oral cavity in less than 60 seconds.
A composition comprising particles including co-spray-dried mannitol and sorbitol, wherein said particles have a nonfilamentous microstructure and said composition is highly compactible.
A method for producing a directly compressible quick-dissolving composition, said method comprising:
- a) dissolving mannitol powder and sorbitol powder into a solution;
- b) drying the solution in an air stream;
- and
- c) adding a disintegrant,
- thereby forming a directly compressible quick-dissolving composition.
A composition comprising:
- (a) particles including co-spray dried mannitol and sorbitol, wherein the particles have a nonfilamentous microstructure;
- (b) a disintegrant selected from the group consisting of crospovidone, croscarmellose, sodium starch glycolate, and combinations thereof;
- (c) a glidant selected from the group consisting of silica gel, colloidal silica, precipitated silica, and combinations thereof;
- and
- (d) an active ingredient.
A quick-dissolving composition comprising:
- (a) particles including co-spray dried mannitol and sorbitol;
- (b) a disintegrant selected from the group consisting of crospovidone, croscarmellose, sodium starch glycolate, and combinations thereof;
- (c) a glidant selected from the group consisting of silica gel, and colloidal silica, precipitated silica, and combinations thereof;
- and
- (d) an active ingredient.
Dependencies are inferred from the claim text.