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US 2003/0118641 A1Published application
Abuse-resistant sustained-release opioid formulation
AssigneeRoxane Laboratories, Inc.
InventorsAnn Maloney, Debra Marie Murwin, Michael Jay Schobelock
Life of this patent
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Abstract
A method for reducing the abuse potential of an oral dosage form of an opioid extractable by commonly available household solvents said method comprising combining a therapeutically effective amount of the opioid compound, or a salt thereof, a matrix-forming polymer and an ionic exchange resin.
Claims6
A method for reducing the abuse potential of an oral dosage form of an opioid extractable by a solvent selected from the group consisting of:
- 70% isopropyl alcohol, 100 proof vodka, white vinegar, 88° C. water, 3% hydrogen, 0.01 N HCl, or 50% aqueous ethanol, said method comprising combining a therapeutically effective amount of the opioid compound, or a salt thereof, between 30 and 65% of a matrix-forming polymer and between 5 and 15% ionic exchange resin.
A method for reducing the abuse potential of an oral dosage form of an opioid extractable by a solvent selected from the group consisting of:
- 70% isopropyl alcohol, 100 proof vodka, white vinegar, 88° C. water, 3% hydrogen, 0.01 N HCl, or 50% aqueous ethanol, said method comprising combining a therapeutically effective amount of an opioid compound, or a salt thereof, between 30 and 65% of a matrix-forming polymer and between 5 and 15% ionic exchange resin having a mean particle size of less than about 50 μm and a particle size distribution such that not less than 90% of the particles pass through a 325 mesh sieve, US. Standard Sieve Size.
Dependencies are inferred from the claim text.