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AssigneeNordic Vaccine Technology A/S
InventorsKristian Dalsgaard, Nikolai Soren Kirkby
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The present invention pertains to complexes comprising sterols and saponins. The complexes are capable of binding a genetic determinant including a polynucleotide. The complexes may further comprise a lipophilic moiety, optionally a lipophilic moiety comprising a contacting group and/or a targeting ligand, and/or a saccharide moiety. The complexes may further comprise an immunogenic determinant and/or an antigenic determinant and/or a medicament and/or a diagnostic compound. The complexes may in even further embodiments be encapsulated by an encapsulation agent including a biodegradable microsphere. The present invention also pertains to pharmaceutical compositions and methods of treatment of an individual by therapy and/or surgery, methods of cosmetic treatment, and diagnostic methods practised on the human or animal body.
Complex comprising
Complex according to any of the preceding claims, wherein the first sterol is selected from the group of sterols consisting of cholesterols, lanosterols, lumisterols, stigmasterols, sitosterols, mycosterols, ergosterols, and thiocholesterols.
Complex according to any of the preceding claims, wherein the first sterol comprises or essentially consists of a cholesterol.
Complex according to any of the preceding claims, wherein the first saponin is selected from the group consisting of first saponins comprising a triterpene glycoside, first saponins comprising a steroid glycoside, and first saponins comprising a steroid alkaloid glycoside.
Complex according to any of the preceding claims, wherein the first saponin comprises or essentially consists of a triterpene glycosid comprising an aglycone compound and a saccharide compound.
Complex according to any of the preceding claims further comprising a lipophilic moiety.
Complex according to any of the preceding claims and further comprising a saccharide component.
Complex according to any of the preceding claims and further comprising a bioactive agent.
Complex according to any of the preceding claims and further comprising a targeting ligand for targeting the complex to a cell surface receptor moiety.
Complex according to any of the preceding claims and further comprising a genetic determinant including a polynucleotide.
Complex according to any of the preceding claims, wherein the complex further comprises a polypeptide.
Complex according to any of the preceding claims, wherein the complex further comprises an immunogenic determinant.
Complex according to any of the preceding claims, wherein the complex further comprises a medicament used for treatment of a human or animal body by therapy.
Complex according to any of the preceding claims, wherein the complex further comprises a compound used for practising a diagnostic method on a human or animal body.
Complex according to any of the preceding claims, wherein the complex has a spherical shape and a diameter in the range of from 25 nm til 75 nm.
Dependencies are inferred from the claim text.