Anticancer activity of imino acid conjugates of methylglyoxal
AssigneeDabur Research Foundation
InventorsAnand C. Burman, Rama Mukherjee, Manu Jaggi, Anu T. Singh, Kamal K. Kapoor, Sudhanand Prasad, Manju Ray
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Abstract
The invention relates to the use of imino acid conjugates of methylglyoxal for the inhibition and/or treatment of cancer. The invention relates more specifically to the use imino acid conjugates of methylglyoxal for inhibition and/or treatment of cancer of the Colon, Prostate, Larynx, Kidney, Pancreas, Lung, Breast, Intestine, Oral cavity, Ovary, Glioblastoma, and Leukemia. The invention also relates to compositions and methods of inhibiting cancer using imino acid conjugates of methylglyoxal.
Claims22
A compound of formula (I)
- 10
- wherein
- R1 is a C1-C12 straight or branched alkyl group, benzyl, or phenyl;
- And
- R2 is H or COR3 where R3 is a C1-C6 straight or branched alkyl group, benzyl or phenyl;
- or a pharmaceutically acceptable salt thereof.
A method of treating a cancer patient by inhibiting the Glyceraldehyde 3 phosphate dehydrogenase enzyme by administration of an effective amount of an imino acid conjugate of methylglyoxal to the patient in need thereof.
A method for treating cancer comprising administration of an effective amount of an imino acid conjugate of methylglyoxal to a patient in need thereof.
Dependencies are inferred from the claim text.