Compositions having improved delivery of actives
OwnerDouglas Joseph Dobrozsi, Jerry William Hayes II +2inventors
InventorsDOUGLAS JOSEPH DOBROZSI, JERRY WILLIAM HAYES II, KISHOR JIVANLAL DESAI, BRIAN JAMES ROBBINS
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Abstract
The present invention pertains to compositions having improved delivery of pharmaceutical actives. These compositions comprise pharmaceutical actives in an anhydrous solvent. These compositions may take the form of liquid elixirs placed into the mouth and eventually swallowed, or can be delivered via liquid-filled drops, metered liquid dosing devices, atomizers and liquid-releasing, edible capsules.
Claims20
A composition comprising a pharmaceutical active selected from the group consisting of dextromethorphan, its pharmaceutically-acceptable salts and mixtures thereof in an hydrophilic, water-miscible, anhydrous solvent wherein the active in its un-ionized state has a percent solubility value in the solvent at ambient temperature that is equal to or greater than 0.075% and the active is in it un-ionized state as a monomolecular dispersion in the solvent.
The composition according to claim 2 wherein the pharmaceutical active in the solvent is in a concentration less than or equal to 125% of the percent solubility value of said active.
20 A method for treating respiratory illnesses using a liquid composition of claim 1 wherein the method comprises oral administration of said composition having a total dosage volume of no more than 3.0 mls.
Dependencies are inferred from the claim text.