Transfer compounds, production and use thereof
AssigneeFaustus Forschungs Cie. Translational Cancer Research GmbH
InventorsJohannes Gerdes, Thomas Scholzen, Claudia Wohlenberg
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Abstract
The invention relates to the use of a carboxy-terminal fragment of the Ki-67 protein or of an active part, fragment or homologue thereof as a compound that can be used for intracellular transfer and for the introduction in and the release by the cells. The invention further relates to transfer compounds that contain the above-mentioned Ki-67 protein and to the vectors encoding the same. The invention also relates to corresponding pharmaceutical compositions and to the use of the transfer protein as an excipient or active agent in the treatment of diseases.
Claims27
A method of transferring a compound into a cell, the method comprising associating the compound with a carrier selected from the group consisting of i) a carboxy-terminal fragment of Ki-67 protein, ii) an active part of the fragment, iii) a portion of the fragment, and iv) a homologue of the fragment and contacting the cell with the carrier-associated compound.
A transfer protein comprising one of i) a carboxy-terminal fragment of the Ki-67 protein, ii) an active part of the fragment, iii) a portion of the fragment, and iv) a homologue of the fragment, wherein the transfer protein is not the full-length Ki-67 protein.
Dependencies are inferred from the claim text.