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AssigneeTrustees of Boston University
InventorsCHRISTOF M. NIEMEYER, CHARLES R. CANTOR, TAKESHI SANO, CASSANDRA L. SMITH
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The invention relates to supramolecular bioconjugates and to methods for assembling and utilizing supramolecular bioconjuigates. Supramolecalar bioconjugates comprise a plurality of first nucleic acids and a plurality of mediators wherein each mediator comprises a second nucleic acid complementary to a sequence within said plurality of first nucleic acids. To assemble a supramolecalar bioconjugate, one or more sets of bioreactive agents are coupled to the plurality of mediators, forming a plurality of bioreactive complexes The plurality of bioreactive complexes are hybridized to the plurality of first nucleic acids to form the supramolecular bioconjugate. Bioconjugates can be used to detect and isolate targets, to screen samples for targets such as antigens, to treat patients with multiple agents or to diagnose disorders in the form of a kit.
A method for assembling a supramolecular bioconjugate comprising the steps of:
The method of herein the one or more first nucleic acids are between about 20 to about 60 nucleotides in length.
A method for forming a supramolecular bioconjugate comprising the steps of:
A method for assembling a supramolecular bioconjugate comprising the steps of:
A method for detecting a target antigen in a sample comprising the steps of:
A method of treating a patient with a disorder comprising the steps of:
A supramolecular bioconjugate comprising a plurality of first nucleic acids, a plurality of second nucleic acids, hybridized to said plurality of first nucleic acids, and one or more sets of bioreactive agents non-covalently attached to said plurality of second nucleic acids.
A diagnostic kit comprising a plurality of positioning nucleic acids attached to a solid support in a pre-determined pattern and a plurality of targeting nucleic acids hybridized to the positioning nucleic acids wherein each targeting nucleic acid is connected to a bioreactive agent forming a supramolecular bioconjugate containing a pre-determined array of bioreactive agents.
A therapeutic composition comprising a supramolecular bioconjugate comprising a plurality of positioning nucleic acids attached to a solid support in a regioselective pattern and a plurality of targeting nucleic acids hybridized to the positioning nucleic acids wherein each targeting nucleic acid is connected to a bioreactive agent forming the supramolecular bioconjugate containing a pre-determined array of bioreactive agents.
Dependencies are inferred from the claim text.