Stable formulations of mhc-peptide complexes
OwnerBishwajit Nag, Jeffrey L. Winkelhakeinventors
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Abstract
The present invention provides stable pharmaceutical compositions comprising MHC-peptide complexes and an alkylglycoside detergent. The compositions are useful for inhibiting T-cell mediated immune response associated with various disease, such as autoimmunity, and allergies.
Claims19
A pharmaceutical composition comprising a pharmeceutically acceptable carrier, a therapeutically effective amount an MHC-peptide complex and an alkylglycoside detergent, the MHC-peptid complex consisting of a preselected antigenic peptide and an isolated MHC Class II component.
A method of inhibiting a T cell-mediated immune response in a mammal, the method comprising administering to the mammal a pharmaceutical composition comprising a pharmaceutically acceptable carrier, a therapeutically effective amount an MHC-peptide complex and an alkylglycoside detergent, the MHC-peptide complex consisting of a preselected antigenic peptide and an isolated MHC Class II component.
Dependencies are inferred from the claim text.