Growth factor binding molecules
AssigneeUniversity of South Florida
InventorsSaid Sebti, Andrew D. Hamilton
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Abstract
Growth factor binding molecules having a plurality of peptide loops attached to a non-peptide organic scaffold, preferably having pseudo-six amino acid peptide loops with four amino acid sidechains. The growth factor binding molecules specifically bind various growth factors and are suitable for treating a subject having tumors or restinosis. In one embodiment a platelet-derived growth factor binding molecule is disclosed that is used to inhibit tumor growth and angiogenesis in solid tumors.
Claims17
A growth factor binding compound comprising a plurality of peptide loops attached to a non-peptide organic scaffold.
A growth factor binding compound, of the general structure:
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- wherein R is n-butyl, n-propyl, benzyl, (C1-C12)alkyl, (C7-C18)aralkyl, (C6-C18)aryl, (C1-C12)alkenyl, (C7-C18)aralkenyl, (C1-C12)alkylether, and X are independently cyclic peptide loops of the general structure:
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- wherein R1, R2, R3, and R4, are each amino acid side chains that define a tetrapeptide sequence, wherein said tetrapeptide is covalently attached at the amino and carboxy termini of said tetrapeptide to a 3-aminomethyl-5-aminobenzamide linking group, and wherein said tetrapeptide sequence is selected from the group consisting of GDFD, GDDD, D-ADGD, GDLD, GDAD, GDGY, ADGD, GDSD, GKGF, GKGK, GDND, PDGD, GDDG, and GDDY.
Dependencies are inferred from the claim text.