Hepatocyte growth factor receptor antagonists and uses thereof
OwnerRalph H. Schwall, Kelly H. Taborinventors
Life of this patent
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Abstract
Hepatocyte growth factor (HGF) receptor antagonists are provided. The HGF receptor antagonists include HGF receptor antibodies and fragments thereof. The HGF receptor antagonists can be employed to block binding of HGF to HGF receptors or substantially inhibit HGF receptor activation. The HGF receptor antagonists may be included in pharmaceutical compositions, articles of manufacture, or kits. Methods of treating cancer using the HGF receptor antagonist are also provided.
Claims40
A hepatocyte growth factor (HGF) receptor antagonist which specifically binds to a HGF receptor.
An isolated HGF receptor antagonist which specifically binds to a HGF receptor and comprises amino acid residues 1-220 of FIG. 1A and amino acid residues 1-230 of FIG. 1B.
A method of treating cancer in a mammal, comprising administering an effective amount of HGF receptor antagonist to a mammal diagnosed as having cancer.
An article of manufacture, comprising:
- a container;
- a label on said container;
- and
- a composition contained within said container;
- wherein the composition includes an active agent effective for treating cancer, the label on said container indicates that the composition can be used for treating cancer, and the active agent in said composition comprises HGF receptor antagonist.
A kit, comprising:
- a first container, a label on said container, and a composition contained within said container;
- wherein the composition includes an active agent effective for treating cancer, the label on said container indicates that the composition can be used for treating cancer, and the active agent in said composition comprises HGF receptor antagonist;
- a second container comprising a pharmaceutically-acceptable buffer;
- and
- instructions for using the HGF receptor antagonist to treat cancer.
An article of manufacture, comprising:
- a container;
- a label on said container;
- and
- a composition contained within said container;
- wherein the composition includes an active agent effective for detecting or purifying HGF receptor, the label on said container indicates that the composition can be used for detecting or purifying HGF receptor, and the active agent in said composition comprises HGF receptor antagonist.
A kit, comprising:
- a first container, a label on said container, and a composition contained within said container;
- wherein the composition includes an active agent effective for detecting or purifying HGF receptor, the label on said container indicates that the composition can be used for detecting or purifying HGF receptor, and the active agent in said composition comprising HGF receptor antagonist;
- a second container comprising a pharmaceutically-acceptable buffer;
- and
- instructions for using the HGF receptor antagonist to detect or purify HGF receptor.
Dependencies are inferred from the claim text.