Restoration of platelet aggregation by antibody administration after GPIIB/IIIa antagonist treatment
AssigneeG.D. Searle & Co.
InventorsKevin C. Glenn, Chris P. Carron, Larry P. Feigen, Jimmy D. Page, Jodi A. Pegg
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Abstract
The invention provides a process to restore platelet aggregation by the administration of antibody combining site-containing molecules that specifically bind to a specific class of reversibly-bound GPIIb/IIIa fibrinogen receptor antagonist compounds.
Claims22
A process for restoring platelet aggregation in the blood of a mammalian host treated with a reversibly-bound GPIIb/IIIa receptor antagonist compound that exhibits a plasma half-life of about two hours to about thirty-six hours, and a GPIIb/IIIa receptor off-rate of about 0.7/seconds (t½˜1 second) to 0.012/seconds (t½˜60 seconds), or a pharmaceutically acceptable salt of said compound, that comprises the steps of:
- (a) contacting the blood of said host with a therapeutically effective amount of antibody combining site-containing molecules that specifically bind to said GPIIb/IIIa receptor antagonist compound to form antibody-treated blood;
- and
- (b) maintaining said antibody-treated blood for a period of time sufficient to restore platelet aggregation.
A process for restoring platelet aggregation in the blood of a mammalian host treated with a reversibly-bound GPIIb/IIIa receptor antagonist compound that exhibits a plasma half-life of about two hours to about thirty-six hours, and a GPIIb/IIIa receptor off-rate of about 0.7/seconds (t½˜1 second) to 0.012/seconds (t½˜60 seconds), or a pharmaceutically acceptable salt of said compound, that comprises the steps of:
- (a) contacting the blood of said host in vivo with a therapeutically effective amount of antibody combining site-containing molecules that specifically bind to said GPIIb/IIIa receptor antagonist compound to form antibody-treated blood;
- and
- (b) maintaining said antibody-treated blood for a period of time sufficient to restore platelet aggregation.
Dependencies are inferred from the claim text.