Adsorbent for oral administration

A pharmaceutical composition comprising a porous spherical carbonaceous substance wherein a diameter is 0.01 to 1 mm, a specific surface area determined by a BET method is 700 m2/g or more, a volume of pores having a pore diameter of 20 to 15000 nm is from not less than 0.04 mL/g to less than 0.10 mL/g, a total amount of acidic groups is 0.30 to 1.20 meq/g, and a total amount of basic groups is 0.20 to 1.00 meq/g, and a pharmaceutically acceptable carrier or diluent.

A method for treating or preventing a renal disease, comprising administering to a subject in need thereof, a porous spherical carbonaceous substance wherein a diameter is 0.01 to 1 mm, a specific surface area determined by a BET method is 700 m2/g or more, a volume of pores having a pore diameter of 20 to 15000 nm is from not less than 0.04 mL/g to less than 0.10 mL/g, a total amount of acidic groups is 0.30 to 1.20 meq/g, and a total amount of basic groups is 0.20 to 1.00 meq/g, in an amount effective thereof.

The method according to claim 6, wherein the renal disease is a disease selected from the group consisting of chronic renal failure, acute renal failure, chronic pyelonephritis, acute pyelonephritis, chronic nephritis, acute nephritic syndrome, acute progressive nephritic syndrome, chronic nephritic syndrome, nephrotic syndrome, nephrosclerosis, interstitial nephritis, tubulopathy, lipoid nephrosis, diabetic nephropathy, renovascular hypertension, and hypertension syndrome, and secondary renal diseases caused by these primary diseases.

A method for treating or preventing a liver disease, comprising administering to a subject in need thereof, a porous spherical carbonaceous substance wherein a diameter is 0.01 to 1 mm, a specific surface area determined by a BET method is 700 m2/g or more, a volume of pores having a pore diameter of 20 to 15000 nm is from not less than 0.04 mL/g to less than 0.10 mL/g, a total amount of acidic groups is 0.30 to 1.20 meq/g, and a total amount of basic groups is 0.20 to 1.00 meq/g, in an amount effective thereof.

A process for manufacturing an adsorbent for oral adminstration, comprising the steps of:

• oxidizing a spherical activated carbon wherein a diameter is 0.01 to 1 mm, a specific surface area determined by a BET method is 700 m2/g or more, and a volume of pores having a pore diameter of 20 to 15000 nm is from not less than 0.04 mL/g to less than 0.10 mL/g, in a temperature range of 300 to 800° C. in an atmosphere containing 0.1 to 50% by volume of oxygen, and
• reducing an oxidized spherical activated carbon in a temperature range of 800 to 1200° C. in an atmosphere of a non-oxidizable gas.