Cell-based therapy for the pulmonary system
OwnerDuncan John Stewartinventor
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Abstract
Cell based therapy comprises administration to the lung by injection into the blood system of viable, mammalian cells effective for alleviating or inhibiting the disorder. The cells may express a therapeutic transgene or the cells may be regenerative.
Claims30
A process of alleviating or inhibiting a disorder in a mammalian patient by conducting therapy which comprises administration to the lung by injection into the blood system of the mammalian patient suffering from a disorder, of viable, mammalian cells, said mammalian cells effective for alleviating or inhibiting said disorder.
Genetically modified, viable cells genetically modified to contain an expressible transgene coding for PGIS.
Genetically modified, viable cells genetically modified to contain an expressible transgene coding for CFTR.
A process of preparing transformants of mammalian cells, which comprises transfecting said mammalian cells with at least one gene coding for a factor selected from the group consisting of CFTR, PGIS, Ang-1, vascular endothelial growth factor, fibroblast growth factor, erythropoietin, hemoxygenase, transforming growth factor beta and platelet derived growth factor, to produce transformed cells capable of expressing said factor in vivo.
A process of alleviating or inhibiting a disorder in a mammalian patient by conducting therapy which comprises administration to the lung by injection into the blood system of the mammalian patient suffering from a disorder, of viable mammalian cells, said mammalian cells effective for tissue regeneration.
A process of alleviating or inhibiting pulmonary hypertension in a mammalian patient by conducting therapy which comprises administration to the mammalian patient an angiogenic factor or a gene which expresses an angiogenic factor.
Dependencies are inferred from the claim text.