Axon repair
OwnerHoward Bomze, Ketan Bulsara +3inventors
InventorsHoward Bomze, Ketan Bulsara, Bermans Iskandar, Pico Caroni, Pate Skene
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Abstract
The present invention relates generally to methods of effecting axon repair.
Claims22
A method of stimulating axon repair or regeneration at a central nervous system injury site in a patient comprising introducing into neuron cell bodies present at said injury site two or more members of a family of growth cone proteins that are missing or deficient in adult neurons, wherein said introduction is effected under conditions such that said stimulation is effected.
A method of stimulating axon repair or regeneration at a central nervous system injury site in a patient comprising contacting neurons present at said injury site with an agent that activates expression of two or more members of a family of growth cone proteins that are missing or deficient in adult neurons, under conditions such that said stimulation is effected.
A method of screening a test compound for its ability to stimulate axon repair or regeneration comprising contacting adult neurons with said test compound and assaying for activation of expression of two or more members of a family of growth cone proteins that are missing or deficient in said adult neurons in the absence of said test compound, wherein a test compound that activates said expression is a candidate agent for use in stimulating axon repair or regeneration.
Dependencies are inferred from the claim text.