Target cell-specific adenoviral vectors containing E3 and methods of use thereof
AssigneeCell Genesys, Inc.
InventorsDaniel R. Henderson, De Chao Yu
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Abstract
The invention provides adenoviral vectors (preferably replication competent) comprising both an E3 sequence and at least one adenoviral gene under transcriptional control of a target cell-specific transcriptional response element. These vectors display significantly improved cytotoxicity, which is especially useful in the cancer context, in which selective destruction of target cells is desirable. The invention further provides host cells comprising the vectors. The invention further provides methods of using the adenoviral vectors.
Claims68
An adenovirus vector comprising
- (a) an adenovirus gene under transcriptional control of a target cell-specific transcriptional regulatory element (TRE);
- and
- (b) an E3 sequence.
An adenovirus vector comprising (a) an E3 sequence;
- and (b) a first adenovirus gene under transcriptional control of a first target cell-specific transcriptional response element (TRE) and a second gene under transcriptional control of a second target cell-specific TRE.
A replication competent adenovirus vector comprising an E3 sequence under transcriptional control of a target cell-specific TRE.
Dependencies are inferred from the claim text.