Modified viral surface proteins for binding to extracellular matrix components
AssigneeUniversity of Southern California
InventorsFrederick L. Hall, Erlinda Maria Gordon, W. French Anderson, Vaughn A. Starnes
Life of this patent
Estimating the term…
Abstract
A viral or non-viral vector particle having a modified viral surface protein wherein the viral surface protein is modified to include a targeting polypeptide including a binding region which binds to an extracellular matrix component. Such vector particles are useful in delivering genes encoding therapeutic agents to cells located at the site of an exposed extracellular matrix component.
Claims19
A vector particle having a modified viral surface protein for targeting the vector particle to an extracellular matrix component, wherein said viral surface protein is modified to include a targeting polypeptide including a binding region which binds to an extracellular matrix component.
A modified polynucleotide encoding a modified viral surface protein for targeting a vector to an extracellular matrix component, wherein the modified polynucleotide includes a polynucleotide encoding a targeting polypeptide, said targeting polypeptide including a binding region which binds to an extracellular matrix component.
A modified retroviral envelope polypeptide wherein, prior to modification, the envelope includes a polypeptide having the sequence (SEQ ID NO:1), and wherein, in the modified envelope, a targeting polypeptide including a binding region which binds to an extracellular matrix component is inserted between amino acid residue 18 and amino acid residue 19 of (SEQ ID NO:1).
A proteoliposome including a wall, wherein said wall of said proteoliposome includes a targeting polypeptide including a binding region which binds to an extracellular matrix component.
Dependencies are inferred from the claim text.