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AssigneeSupratek Pharma Inc.
InventorsAlexander V. Kabanov, Pierre Lemieux, Valery Yulievich Alakhov, Sergey V. Vinogradov
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Compositions induce the activation of dendritic cells comprising a polynucleotide, such as viruses, RNA, DNA, plasmid DNA, or derivatives thereof and at least one block copolymer of alkylethers. The present invention further relates to compositions for inducing the activation of dendritic cells wherein the block copolymers are PLURONIC F127 and L61. More particular, the compositions comprise block copolymers PLURONIC F127/PLURONIC L61. The invention also relates to methods of inducing the activation of dendritic cells in animals comprising administering the compositions of the invention. Additionally, the present invention relates to methods of increasing the immune response of animals comprising administering the compositions of the present invention.
Composition for inducing activation of dendritic cells comprising a polynucleotide, viral vector, or polynucleotide derivative thereof and at least one polyoxyethylene-polyoxypropylene block copolymer.
A composition for inducing the activation of dendritic cells comprising a polynucleotide or derivative thereof and at least one polyoxyethylene-polyoxypropylene block copolymer, wherein the block copolymer is present at a concentration below about 15% wt/vol.
A composition for inducing the activation of dendritic cells comprising a polynucleotide or derivative thereof and at least one polyoxyethylene-polyoxypropylene block copolymer, wherein the composition forms a molecular solution or colloidal dispersion.
A method of inducing activation of dendritic cells comprising administering a composition comprising a polynucleotide or derivative thereof and at least one polyoxyethylene-polyoxypropylene block copolymer.
The method of claim 30 wherein the block copolymers comprise at least PLURONIC F127 and L61.
A method of inducing activation of dentritic cells comprising administering a composition comprising a polynucleotide or derivative thereof and at least one polyoxyethylene-polyoxypropylene block copolymer, wherein the composition forms a molecular solution or colloidal dispersion.
A compostion for inducing the activation of dentritic cells comprising at least one polyoxyethylene-polyoxypropylene block copolymer.
A composition for inducing the activation of dendritic cells comprising at least one polyoxyethylene-polyoxypropylene block copolymer, wherein the composition forms a molecular solution or colloidal dispersion.
A composition for inducing activation of dendritic cells comprising a polynucleotide or derivative thereof and at least one polycationic polymer having a plurality of cationic repeating units.
A composition according to claim 69 wherein the polycationic polymer is covalently linked with at least one nonionic polymer segment.
A method of inducing activation of dendritic cells comprising administering a composition comprising a polynucleotide or derivative thereof and at least one polyoxyethylene-polyoxypropylene block copolymer.
A method of inducing the activation of dendritic cells comprising administering a composition comprising at least one polyoxyethylene-polyoxypropylene block copolymer, wherein the block copolymer is present in amounts insufficient for gel formation.
A method of inducing activation of dentritic cells comprising administering a composition comprising at least one polyoxyethylene-polyoxypropylene block copolymer, wherein the composition forms a molecular solution or colloidal dispersion.
Dependencies are inferred from the claim text.