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AssigneeHuman Genome Sciences, Inc.
InventorsYing-Fei Wei, Jian Ni, Reiner L. Gentz, Steven M. Ruben
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The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as “TNFR-5” or “TR5,” and now referred to hereinafter as “TRAIL receptor without intracellular domain” or “TRID.” TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.
A method for treating graft versus host disease, viral infection, cancer, leukemia, immunodeficiency, or an autoimmune disorder comprising administering to an individual therapeutically effective amounts of:
A composition comprising:
An isolated polypeptide comprising an amino acid sequence at least 90% identical to amino acids 27 to 240 of SEQ ID NO:2;
An isolated nucleic acid molecule comprising a polynucleotide encoding an amino acid sequence at least 90% identical to amino acids 27 to 240 of SEQ ID NO:2.
An isolated nucleic acid molecule comprising a polynucleotide encoding an amino acid sequence at least 90% identical to the amino acid sequence of the mature polypeptide encoded by the cDNA clone in ATCC Deposit No. 97798.
An isolated polypeptide comprising an amino acid sequence at least 90% identical to amino acids 27 to 240 of SEQ ID NO:2.
An isolated polypeptide comprising an amino acid sequence at least 90% identical to the amino acid sequence of the mature polypeptide encoded by the cDNA clone contained in ATCC Deposit No. 97798.
An isolated antibody which binds to a polypeptide consisting of amino acids 1 to 259 of SEQ ID NO:2.
An isolated antibody which binds to a polypeptide consisting of the amino acid sequence of the complete polypeptide encoded by the cDNA clone contained in ATCC Deposit No. 97798.
Dependencies are inferred from the claim text.