Methods of using 46828, a human acyl-CoA synthetase
AssigneeMillennium Pharmaceuticals, Inc.
InventorJohn Joseph Hunter
Life of this patent
Estimating the term…
Abstract
Isolated nucleic acids molecules, designated 46828 nucleic acid molecules, which encode AMP-binding enzymes, and in particular acyl-CoA synthases are disclosed. The invention provides methods of modulating the differentiation, proliferation, and/or inducing the cell killing of 46828-expressing hyperproliferative cells, e.g., 46828-expressing malignant cells from the lung, colon and ovaries. The invention further provides methods of treating, preventing and diagnosing solid tumors, soft tissue tumors, and/or metastatic lesions.
Claims7
A method of inhibiting proliferation, or inducing the killing, of a 46828-expressing hyperproliferative cell, comprising contacting the hyperproliferative cell with a compound that modulates the activity or expression of a 46828 polypeptide or nucleic acid, in an amount which is effective to reduce or inhibit the proliferation of, or induce the killing of, the hyperproliferative cell.
A method of treating or preventing a disorder characterized by aberrant cellular proliferation or differentiation of a 46828-expressing cell, in a subject, comprising:
- administering to the subject an effective amount of a compound that modulates the activity or expression of a 46828 polypeptide;
- such that the aberrant cellular proliferation or differentiation of the 46828-expressing cell is reduced or inhibited.
Dependencies are inferred from the claim text.