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AssigneeTherics, Inc.
InventorsJill K. Sherwood, Donald Monkhouse, Christopher M. Gaylo
Estimating the term…
The devices disclosed herein are composite implantable devices having a gradient of one or more of the following: materials, macroarchitecture, microarchitecture, or mechanical properties, which can be used to select or promote attachment of specific cell types on and in the devices prior to and/or after implantation. In preferred embodiments, the implants include complex three-dimensional structure, including curved regions and saddle-shaped areas. In various embodiments, the gradient forms a transition zone in the device from a region composed of materials or having properties best suited for one type of tissue to a region composed of materials or having properties suited for a different type of tissue. Methods to improve these devices for use in repair or replacement of cartilage and/or bone have been developed, which specifically address 1) the selection of the appropriate polymeric material for the cartilage region, 2) mechanical testing of the bone region including the effect of porosity and polymer/calcium phosphate ratio, and 3) prevention of delamination in the transition region.
A composite medical implant comprising
A method to reduce delamination between regions of an implant comprising one or more of the following steps selected from the group consisting of
A method of repairing or replacing tissue comprising implanting into a patient a composite medical implant comprising multiple regions having a different composition, the regions comprising a combination of structure and chemical composition varying from one region to another region to prevent delamination and to promote cell seeding, cell attachment, cell ingrowth or differentiation of cells when implanted into a patient.
A method of making a composite implant, comprising:
Dependencies are inferred from the claim text.