Methods for measuring retinal damage
AssigneeAllergan Sales, Inc.
InventorsRobert David, Michael Belkin
Life of this patent
Estimating the term…
Abstract
Methods for measuring retinal damage resulting from an injury include calculating the slope of retinal thickness from the injury site to the periphery of the site. A shallower slope of retinal thickness correlates with a greater degree of damage resulting from the injury. The methods may also be useful to screen pharmaceuticals for potential neuroprotective effects against retinal injuries.
Claims21
A method for measuring retinal damage in a subject, which damage results from a focal injury to a retina, the method comprising the step of calculating a slope of retinal thickness between a plurality of locations of the retina, wherein the amount of retinal damage correlates to the slope of retinal thickness.
A method for measuring retinal damage in a subject, which damage is caused by a laser, the method comprising the step of measuring a slope of retinal thickness between a plurality of locations of the retina, wherein the amount of retinal damage correlates to the slope of retinal thickness.
A method for measuring retinal damage in a subject, which damage is caused by a laser, the method comprising the steps of:
- (i) measuring the thickness of the retina, which has been exposed to a laser, at a plurality of locations of the retina;
- and
- (ii) calculating the slope of retinal thickness from a site exposed to the laser to a site that is peripheral to the site exposed to the laser, wherein the amount of retinal damage correlates to the slope of retinal thickness.
A method for determining neuroprotective effects of an ophthalmic solution, the method comprising the steps of:
- (i) administering a potential neuroprotective agent in an ophthalmic composition to a subject;
- (ii) measuring the thickness of a retina in a subject, which has been exposed to a laser, at a plurality of locations of the retina;
- and
- (iii) calculating the slope of retinal thickness from a lesion of the laser to the periphery of the lesion, wherein the neuroprotective effect of the ophthalmic composition correlates with greater slope of retinal thickness.
Dependencies are inferred from the claim text.