Process for the preparation of phenethylamine derivatives
AssigneeSandoz Ltd.
InventorsNiranjan Paingankar, Vilas Mumbaikar, Vadiraj S Ekkundi, Hans-Peter Jalett, Urs Siegrist, Paul Adriaan Van Der Schaaf, Frank Bienewald, Martin Studer, Stefan Burkhardt
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Abstract
Disclosed is a process for the preparation of a compound of formula 1 wherein R1 is hydrogen, hydroxyl, or unsubstituted or substituted alkyl or alkoxy, R2 is hydrogen or a substituent which can be converted to hydrogen, and n is 0, 1 or 2, comprising hydrogenating a compound of formula 2 wherein R1, R2 and n are as defined above, in the presence of a nickel or cobalt catalyst.
Claims19
A process for the preparation of a compound of formula
- 10
- or salts thereof, wherein
- R1 is hydrogen, hydroxyl, or unsubstituted or substituted alkyl or alkoxy,
- R2 is hydrogen or a substituent which can be converted to hydrogen, and
- n is 0, 1 or 2,
- comprising hydrogenating a compound of formula
- 11
- wherein R1, R2 and n are as defined above, in the presence of a nickel or cobalt catalyst.
A process for the preparation of a compound of formula
- 14
- wherein
- R1 is hydrogen, hydroxyl, or unsubstituted or substituted alkyl or alkoxy,
- R2 is hydrogen or a substituent which can be converted to hydrogen, and
- n is 0, 1 or 2,
- comprising hydrogenating a compound of formula
- 15
- wherein R1, R2 and n are as defined above, in the presence of a nickel or colbalt catalyst to give the compound of formula
- 16
- wherein R1, R2 and n are as defined above, and converting the compound of formula (1) to the compound of formula (3).
Dependencies are inferred from the claim text.