Process for the preparation of quinolylpropenal
AssigneesUbe Industries, Ltd., Nissan Chemical Industries, Ltd.
InventorsKatsumasa Harada, Shigeyoshi Nishino, Hidetaka Shima, Takashi Harada, Naoako Okada
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Abstract
3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]prop-2-enal is prepared in a high yield by reducing 3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]prop-2-enenitrite with Raney nickel either in the presence of formic acid and 0.25 to 1 part by volume of water per part by volume of formic acid or in the presence of both an amine salt of formic acid and an organic acid.
Claims9
A method for preparing 3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]prop-2-enal by reducing 3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]prop-2-enenitrite using Raney-nickel in the presence of formic acid and water in an amount of 0.25 to 1 volume part per one volume part of the formic acid, or in the presence of an amine salt of formic acid and an organic acid.
Dependencies are inferred from the claim text.