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US 2003/0114672 A1Published application
Purine inhibitors of protein kinases, G proteins and polymerases
AssigneesThe Regents of the University of California, Centre National De La Recherche Scientifique
InventorsNathanael S. Gray, Peter Schultz, Sung-Hou Kim, Laurent Meijer
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Abstract
The present invention relates to purine analogs that inhibit, inter alia, protein kinases, G-proteins and polymerases. In addition, the present invention relates to methods of using such purine analogs to inhibit protein kinases, G-proteins, polymerases and other cellular processes and to treat cellular proliferative diseases.
Claims25
A compound having the formula.
- 50
- wherein,
- R1, R2, R, R4 and R5 are independently members selected from the group consisting of H, C1-C8 straight-chain, branched-chain, saturated and unsaturated alkyl, C1-C8 straight-chain, branched-chain, saturated and unsaturated substituted alkyl, aryl and substituted aryl.
Dependencies are inferred from the claim text.