Antibacterial agents

A compound of Formula II:

• 399
• or a tautomer or pharmaceutically acceptable salt thereof wherein:
• R1 is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heterocyclic and substituted heterocyclic,
• or heteroaryl and substituted heteroaryl;
• R2 is H,
• 400
• wherein Rc is
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl,defined as above;
• R3, R4, and R6 independently are H,
• OH,
• (O)nC1-C7 alkyl and substituted alkyl,
• (O)nC2-C7 alkenyl and substituted alkenyl,
• (O)nC2-C7 alkynyl and substituted alkynyl,
• wherein n is 0 or 1,
• halo,
• NO2,
• CN,
• NRaRb, wherein Ra and Rb are each independently H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• C5-C8 cycloalkenyl and substituted cycloalkenyl,
• aryl and substituted aryl, or
• 401
• wherein Rc is
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl,defined as above;
• 402
• wherein Rd and Re are independantly H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl;
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl, or
• Ra and Rb taken together with the nitrogen to which they are attached form a 4, 5, 6, 7, or 8 membered ring having from 0 to 3 heteroatoms selected from N, O, and S, wherein said ring is optionally substituted by one or more substituents;
• R1 and R6 taken together with the atoms to which they are attached to form a 5, 6, 7, or 8 membered ring having from 0 to 3 heteroatoms selected from N, O, and S, wherein said ring is optionally substituted by one or more substituents;
• R5 is hydrogen,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• 403
• wherein Rc is defined as above,
• 404
• wherein Z is O or N Rd and Re are defined as above and p is 0 or 1;
• halo,
• NO2,
• CN,
• NRfRg, wherein Rf and Rg are defined as for Ra and Rb above;
• aryl or fused aryl, f
• heterocyclic or fused heterocyclic,
• heteroaryl or fused heteroaryl, or
• bicyclic heterocyclic or spiro heterocyclic;
• wherein fused aryl, fused heterocyclic, fused heteroaryl, bicyclic heterocyclic, or spiro heterocyclic can be substituted.

A compound of Formula III:

• 406
• or a tautomer or pharmaceutically acceptable salt thereof wherein:
• R1 is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heterocyclic and substituted heterocyclic,
• or heteroaryl and substituted heteroaryl;
• R2 is H,
• 407
• wherein Rc is
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl,defined as above;
• R3, and R4 independently are H,
• OH,
• (O)nC1-C7 alkyl and substituted alkyl,
• (O)nC2-C7 alkenyl and substituted alkenyl,
• (O)nC2-C7 alkynyl and substituted alkynyl,
• wherein n is 0 or 1,
• halo,
• NO2,
• CN,
• NRaRb, wherein Ra and Rb are each independently H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• C5-C8 cycloalkenyl and substituted cycloalkenyl,
• aryl and substituted aryl, or
• 408
• wherein Rc is
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl,defined as above;
• 409
• wherein Rd and Re are independently H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl;
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl, or
• Ra and Rb taken together with the nitrogen to which they are attached form a 4, 5, 6, 7, or 8 membered ring having from 0 to 3 heteroatoms selected from N, O, and S, wherein said ring is optionally substituted by one or more substituents;
• R5 is hydrogen,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• 410
• wherein Rc is defined as above,
• 411
• wherein Z is O or N Rd and Re are defined as above and p is 0 or 1;
• halo,
• NO2,
• CN,
• NRfRg, wherein Rf and Rg are defined as for Ra and Rb above;
• aryl or fused aryl,
• heterocyclic or fused heterocyclic,
• heteroaryl or fused heteroaryl, or
• bicyclic heterocyclic or spiro heterocyclic,
• wherein fused aryl, fused heterocyclic, fused heteroaryl, bicyclic heterocyclic, or spiro heterocyclic can be substituted.

A compound of Formula IV:

• 413
• or a pharmaceutically acceptable salt thereof wherein:
• R1 is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heterocyclic and substituted heterocyclic,
• or heteroaryl and substituted heteroaryl;
• R2 is H,
• 414
• wherein Rc is
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl,defined as above;
• R3 and R6 independently are H,
• OH,
• (O)nC1-C7 alkyl and substituted alkyl,
• (O)nC2-C7 alkenyl and substituted alkenyl,
• (O)nC2-C7 alkynyl and substituted alkynyl,
• wherein n is 0 or 1,
• halo,
• NO2,
• CN,
• NRaRb, wherein Ra and Rb are each independently H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• C5-C8 cycloalkenyl and substituted cycloalkenyl,
• aryl and substituted aryl, or
• 415
• wherein Rc is
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl,defined as above;
• 416
• wherein Rd and Re are independantly H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl;
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl, or
• Ra and Rb taken together with the nitrogen to which they are attached form a 5, 6, 7, or 8 membered ring having from 0 to 3 heteroatoms selected from N, O, and S, wherein said ring is optionally substituted by one or more substituents;
• R1 and R6 can be taken together with the atoms to which they are attached form a 5, 6, 7, or 8 membered ring having from 0 to 3 heteroatoms selected from N, O, and S, wherein said ring is optionally substituted by one or more substituents;
• R5 is hydrogen,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• 417
• wherein Rc is defined as above,
• 418
• wherein Z is O or N Rd and Re are defined as above and p is 0 or 1;
• halo,
• NO2,
• CN,
• NRfRg, wherein Rf and Rg are defined as for Ra and Rb above;
• aryl or fused aryl,
• heterocyclic or fused heterocyclic,
• heteroaryl or fused heteroaryl,
• bicyclic heterocyclic or spiro heterocyclic,
• wherein fused aryl, fused heterocyclic, fused heteroaryl, bicyclic heterocyclic, or spiro heterocyclic can be substituted.

A compound of Formula V:

• 420
• or a tautomer or pharmaceutically acceptable salt thereof wherein:
• R1 is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heterocyclic and substituted heterocyclic,
• or heteroaryl and substituted heteroaryl;
• R2 is H,
• 421
• wherein Rc is
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl,defined as above;
• R3 is H,
• OH,
• (O)nC1-C7 alkyl and substituted alkyl,
• (O)nC2-C7 alkenyl and substituted alkenyl,
• (O)nC2-C7 alkynyl and substituted alkynyl,
• wherein n is 0or 1,
• halo,
• NO2,
• CN,
• NRaRb, wherein Ra and Rb are each independently H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• C5-C8 cycloalkenyl and substituted cycloalkenyl,
• aryl and substituted aryl, or
• 422
• wherein Rc is
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl,defined as above;
• 423
• wherein Rd and Re are independantly H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl;
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl, or
• Ra and Rb taken together with the nitrogen to which they are attached form a 5, 6, 7, or 8 membered ring having from 0 to 3 heteroatoms selected from N, O, and S, wherein said ring is optionally substituted by one or more substituents;
• R5 is hydrogen,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• 424
• wherein Rc is defined as above,
• 425
• wherein Z is O or N Rd and Re are defined as above and p is 0 or 1;
• halo,
• NO2,
• CN,
• NRfRg, wherein Rf and Rg are defined as for Ra and Rb above;
• aryl or fused aryl,
• heterocyclic or fused heterocyclic,
• heteroaryl or fused heteroaryl,
• bicyclic heterocyclic or spiro heterocyclic,
• wherein fused aryl, fused heterocyclic, fused heteroaryl, bicyclic heterocyclic, or spiro heterocyclic can be substituted.

A compound of formula VI:

• 427
• or a tautomer or pharmaceutically acceptable salt thereof wherein:
• R1 is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heterocyclic and substituted heterocyclic,
• or heteroaryl and substituted heteroaryl;
• R2 is H,
• 428
• wherein Rc is
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl,defined as above;
• R3, R4, and R6 independently are H,
• OH,
• (O)nC1-C7 alkyl and substituted alkyl,
• (O)nC2-C7 alkenyl and substituted alkenyl,
• (O)nC2-C7 alkynyl and substituted alkynyl,
• wherein n is 0 or 1,
• halo,
• NO2,
• CN,
• NRaRb, wherein Ra and Rb are each independently H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• C5-C8 cycloalkenyl and substituted cycloalkenyl,
• aryl and substituted aryl, or
• 429
• wherein Rc is
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl,defined as above;
• 430
• wherein Rd and Re are independantly H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl;
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl, or
• Ra and Rb taken together with the nitrogen to which they are attached form a 5, 6, 7, or 8 membered ring having from 0 to 3 heteroatoms selected from N, O, and S, wherein said ring is optionally substituted by one or more substituents;
• R1 and R6 taken together with the atoms to which they are attached form a 5, 6, 7, or 8 membered ring having from 0 to 3 heteroatoms selected from N, O, and S, wherein said ring is optionally substituted by one or more substituents;
• and
• Rf and Rg are defined as for Raand Rb above.

A compound of formula VII:

• 431
• or a tautomer or pharmaceutically acceptable salt thereof wherein:
• R1 is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heterocyclic and substituted heterocyclic,
• or heteroaryl and substituted heteroaryl;
• R2 is H,
• 432
• wherein Rc is
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl,defined as above;
• R3, and R4 independently are H,
• OH,
• (O)nC1-C7 alkyl and substituted alkyl,
• (O)nC2-C7 alkenyl and substituted alkenyl,
• (O)nC2-C7 alkynyl and substituted alkynyl,
• wherein n is 0 or 1,
• halo,
• NO2,
• CN,
• NRaRb, wherein Ra and Rb are each independently H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• C5-C8 cycloalkenyl and substituted cycloalkenyl,
• aryl and substituted aryl, or
• 433
• wherein Rc is
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl,defined as above;
• 434
• wherein Rd and Re are independantly H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl;
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl, or
• Ra and Rb taken together with the nitrogen to which they are attached form a 4, 6, 7, or 8 membered ring having from 0 to 3 heteroatoms selected from N, O, and S, wherein said ring is optionally substituted by one or more substituents;
• and
• Rf and Rg are defined as for Raand Rb above.

A compound of formula VIII:

• 435
• or a tautomer or pharmaceutically acceptable salt thereof wherein:
• R2 is H,
• 436
• wherein Rc is
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl,defined as above;
• R3 and R4 independently are H,
• OH,
• (O)nC1-C7 alkyl and substituted alkyl,
• (O)nC2-C7 alkenyl and substituted alkenyl,
• (O)nC2-C7 alkynyl and substituted alkynyl,
• wherein n is 0 or 1,
• halo,
• NO2,
• CN,
• NRaRb, wherein Ra and Rb are each independently H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• C5-C8 cycloalkenyl and substituted cycloalkenyl,
• aryl and substituted aryl, or
• 437
• wherein Rc is
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl,defined as above;
• 438
• wherein Rd and Re are independantly H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl;
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl, or
• Ra and Rb taken together with the nitrogen to which they are attached form a 4, 6, 7, or 8 membered ring having from 0 to 3 heteroatoms selected from N, O, and S, wherein said ring is optionally substituted by one or more substituents;
• R5 is hydrogen,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• 439
• wherein Rc is defined as above,
• 440
• wherein Z is O or N Rd and Re are defined as above and p is 0 or 1;
• halo,
• NO2,
• CN,
• NRfRg, wherein Rf and Rg are defined as for Ra and Rb above;
• aryl or fused aryl,
• heterocyclic or fused heterocyclic,
• heteroaryl or fused heteroaryl,
• bicyclic heterocyclic or spiro heterocyclic,
• wherein fused aryl, fused heterocyclic, fused heteroaryl, bicyclic heterocyclic, or spiro heterocyclic can be substituted;
• X and Y each independently are O, CH2, CH(C1-C7 alkyl), C(C1-C7 alkyl)2, C(C3-C6 cycloalkyl),
• 441
• wherein
• 442
• is a C3-C6 cycloalkyl, NH, N(C1-C7 alkyl), S, SO, or SO2;
• m is 0-14;
• Rh is H,
• OH,
• (O)nC1-C7 alkyl and substituted alkyl,
• (O)nC2-C7 alkenyl and substituted alkenyl,
• (O)nC2-C7 alkynyl and substituted alkynyl,
• wherein n is 0 or 1,
• halo,
• NO2,
• CN,
• NRjRk,
• wherein Rj and Rk independently are H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• 443
• alkyl and substituted alkyl, or
• Rj and Rk taken together with the nitrogen to which they are attached form a 3- to 7-membered ring containing from 1 to 3 heteroatoms selected from N, O, and S, said ring being unsubstituted or substituted with 1, 2, 3, or 4 substituent groups.

A compound of formula IX:

• 444
• or a pharmaceutically acceptable salt thereof wherein:
• R1 is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heterocyclic and substituted heterocyclic,
• or heteroaryl and substituted heteroaryl;
• R2 is H,
• 445
• wherein Rc is
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl,defined as above;
• R3, R4, and R6 independently are H,
• OH,
• (O)nC1-C7 alkyl and substituted alkyl,
• (O)nC2-C7 alkenyl and substituted alkenyl,
• (O)nC2-C7 alkynyl and substituted alkynyl,
• wherein n is 0 or 1,
• halo,
• NO2,
• CN,
• NRaRb, wherein Ra and Rb are each independently H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• C5-C8 cycloalkenyl and substituted cycloalkenyl,
• aryl and substituted aryl, or
• 446
• wherein Rc is
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl,defined as above;
• 447
• wherein Rd and Re are independantly H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl;
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl, or
• Ra and Rb taken together with the nitrogen to which they are attached form a 4, 5, 6, 7, or 8 membered ring having from 0 to 3 heteroatoms selected from N, O, and S, wherein said ring is optionally substituted by one or more substituents;
• R1 and R6 taken together with the atoms to which they are attached form a 5, 6, 7, or 8 membered ring having from 0 to 3 heteroatoms selected from N, O, and S, wherein said ring is optionally substituted by one or more substituents;
• 448
• is aryl or fused aryl,
• heterocyclic or fused heterocyclic,
• heteroaryl or fused heteroaryl,
• bicyclic heterocyclic or spiro heterocyclic,
• wherein fused aryl, fused heterocyclic, fused heteroaryl, bicyclic heterocyclic, or spiro heterocyclic can be substituted;
• V is N, CH, or C, provided that when Z is N or CH, “- -” is absent and when Z is C, “” is a double bond;
• z is 0, 1, 2, or 3;
• V′ is O, S, NH2, NHR″, wherein R″ is C1-C7 alkyl and substituted alkyl;
• R′ is
• 449
• wherein Rc is defined as above,
• 450
• and
• wherein J and K independently are C or N, provided that when J or K is N, R4 or R6 is absent at that position.

The invention also provides a compound which is:

• 7-(6-amino-3-aza-bicyclo[3.1.0]hex-3-yl)-6-fluoro-3H-1-methylcyclopropyl-1H-quinazoline-2,4-dione (1α, 5α, 6α) hydrochloride,
• 1-Cyclopropyl-6-fluoro-8-methyl-7-[(R)-3-((S)-1-methylaminoethyl)-pyrrolidin-1-yl]-1H-quinazoline-2,4-dione,
• 1-Cyclopropyl-6-fluoro-8-methoxy-7-[(R)-3-((S)-1-methylaminoethyl)-pyrrolidin-1-yl]-1H-quinazoline-2,4-dione,
• 7-[(R)-3-((S)-1-Aminoethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione hydrochloride,
• 1-Cyclopropyl-7-dimethylamino-6-fluoro-8-methyl-1H-quinazoline-2,4-dione,
• 7-((S)-3-Amino-pyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1H-quinazoline-2,4-dione trifluoroacetic acid,
• 7-(3-[1-Amino-1-(2-fluorophenyl)methyl]-pyrrolidin-1-yl}-1-cyclopropyl-6-fluoro-6-methyl-1H-quinazoline-2,4-dione hydrochloride,
• 1-Cyclopropyl-8-methyl-7-[(R)-3-((S)-1-methylaminoethyl)pyrrolidin-1-yl]-1H-pyrido[4,3-d]pyrimidine-2,4-dione hydrochloride,
• 7-((S)-3-Aminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-1H-pyrido[2,3-d]pyrimidine-2,4-dione hydrochloride,
• 7-[(R)-3-((S)-1-Aminoethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-1H-pyrido[2,3-d]pyrimidine-2,4-dione hydrochloride,
• 7-((S)-3-Aminopyrrolidin-1-yl)-8-fluoro-5-methyl-5,6-dihydropyrrolo[3,2,1-ij]quinazoline-1,3-dione hydrochloride,
• 7-[(R)-3-((S)-1-Aminoethyl)pyrrolidin-1-yl)-8-fluoro-5-methyl-5,6-dihydropyrrolo[3,2, 1-i,j] quinazoline-1,3-dione hydrochloride, 8-((S)-3-Aminopyrrolidin-1-yl)-9-fluoro-5-methyl-6,7-dihydropyrido[3,2, 1-ij]quinazoline-1,3-dione hydrochloride,
• 8-[(R)-3-((S)-1-Aminoethyl)pyrrolidin-1-yl)-9-fluoro-5-methyl-6,7-dihydro-5H-pyrido[3,2,1-i,j] quinazoline-1,3-dione hydrochloride,
• 1-(1-Cyclopropyl-6-fluoro-8-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-7-yl)cyclopropanecarbonitrile,
• 1-(1-Cyclopropyl-6-fluoro-8-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-7-yl)cyclopropanecarboxylic acid amide,
• 7-Amino-9-[9-(R)-3-((S)-1-aminoethyl)pyrrolidin-1-yl)-8-fluoro-3-methyl-2,3-dihydro-1-oxa-3a,5-diazaphenalene-4,6-dione hydrochloride,
• 7-((3aR, 6aS)- and (3aS, 6aR)-4-Aminohexahydrocyclopenta[c]pyrrol-2-yl-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione, hydrochloride,
• 7-((3aR, 6aS)- and (3aS, 6aR)-4-Aminohexahydrocyclopenta[c]pyrrol-2-yl-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione hydrochloride,
• 7-[3-(1-Amino-2-fluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione hydrochloride,
• 7-[3-(Aminocyclopropylmethyl)-pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione hydrochloride,
• 7-(3-Aminomethyl-4-fluoromethylpyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione,
• 7-(5-Aminomethylthiophen-3-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione hydrochloride,
• 1-Cyclopropyl-7-(5,5-difluoro-4-hydroxy-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-6-fluoro-8-methyl-1H-quinazoline-2,4-dione,
• 7-(4-Amino-5,5-difluoro-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione hydrochloride,
• 7-(4-Amino-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione hydrochloride,
• 7-[(R)-3-(1-Aminocyclopropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione hydrochloride,
• 7-(4-Amino-5,6-dihydro-4H-4,5,6,7-tetrahydrobenzo[b]-thiophen-7-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione hydrochloride,
• 1-cyclopropyl-6-fluoro-8-methyl-7-(7-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-1H-quinazoline-2,4-dione,
• 1-Cyclopropyl-6-fluoro-8-methyl-7-(4-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrol-2-yl)-1H-quinazoline-2,4-dione hydrochloride,
• 7-[[(3S, 4R)-3-(R)- and (3R, 4S)-3-(S)]-1-amino-2,2,2-trifluoroethyl)-4-hydroxypyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione,
• 7-[3-(Aminooxazol-4-ylmethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione,
• 7-(3R, 4S)- and 7-((3S, 4R)-3-Aminomethyl-4-fluoropyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoloine-2,4-dione hydrochloride,
• 7-(3-Aminohexahydrofuro[2,3-c]pyrrol-5-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione hydrochloride,
• 7-[4-(Aminoethyl)-3,3-dimethylpyrrolidin-1-yl]-1-cylcopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione hydrochloride,
• 7-(4-Aminooctahydroisoindol-2-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione hydrochloride,
• 7-[(R)-3-((S)-1-Aminoethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-fluoromethoxy-1H-quinazoline-2,4-dione hydrochloride,
• 7-[(R)-3-((S)-1-Aminoethyl)pyrrolidin-1-yl]-1-cyclopropyl-8-difluoromethyl-6-fluoro-1H-quinazoline-2,4-dione hydrochloride,
• 7-[5-(1-Aminocyclopropyl)thiophen-2-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione hydrochloride,
• 7-[(R)-3-(1-Aminocyclopropyl)pyrrolidin-1-yl]-1-cyclopropyl-8-diflouromethoxy-6-fluoro-1H-quinazoline-2,4-dione,
• 7-[(R)-3-((S)-1-Aminoethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-difluoromethoxy-1H-quinazoline-2,4-dione hydrochloride,
• 7-[(R)-3-((S)-1-Aminoethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5,8-dimethyl-1H-quinazoline-2,4-dione hydrochloride,
• 1-Cyclopropyl-8-difluoromethoxy-7-((R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl)-1H-quinazoline-2,4-dione hydrochloride,
• 7-[(R)-3-((S)-1-Aminoethyl)pyrrolidin-1-yl]-1-cyclopropyl-8-difluoromethoxy-1H-quinazoline-2,4-dione hydrochloride,
• 7-((3R, 4S)- and (3S, 4R)-3-Aminomethyl-4-trifluoromethylpyrrolidin-1-yl)-1-cyclopropyl-8-difluoromethoxy-6-fluoro-1H-quinazoline-2,4-dione hydrochloride,
• 1-Cyclopropyl-6-fluoro-8-methoxy-7-[3(R)-1(S)-methylaminoethyl)pyrrolidin-1-yl]-1H-quinazoline-2,4-dione,
• 1-Cyclopropyl-6-fluoro-8-methyl-7-[3(R)-(1(S)-methylaminoethyl)pyrrolidin-1-yl]-1H-quinazoline-2,4-dione,
• 7-(3-Aminopiperidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione,
• 1-Cyclopropyl-6-fluoro-8-methoxy-7-(octahydropyrrolo[3,4-c]pyridin-2-yl)-1H-quinazoline-2,4-dione,
• 7-((S)-3-Aminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione,
• 7-(3-Aminopiperidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione,
• 1-Cyclopropyl-6-fluoro-8-methyl-7-(octahydropyrrolo[3,4-c]pyridin-2-yl)-1H-quinazoline-2,4-dione,
• 7-(3(S)-Aminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione,
• 7-(3-Aminomethyl-3-methylpyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione,
• 7-(3-Aminomethylpyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione,
• 7-[3(R)-(1-Amino-1-methylethyl)-pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione,
• 7-(3-Aminomethylpiperidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione,
• 7-(3-Aminomethyl-3-benzylpyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione,
• 1-Cyclopropyl-6-fluoro-8-methoxy-7-(octahydropyrrolo[3,4-b]pyridin-6-yl)-1H-quinazoline-2,4-dione,
• 7-(1-Amino-5-aza-spiro[2.4]hept-5-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione,
• 7-(3-Aminomethyl-3-methylpyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione,
• 7-[3(R)-(1-Amino-1-methylethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione,
• 1-Cyclopropyl-6-fluoro-8-methyl-7-(octahydropyrrolo[3,4-b]pyridin-6-yl)-1H-quinazoline-2,4-dione,
• 7-(3a-Aminomethyloctahydroisoindol-2-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione,
• 7-(3S, 4R)- and 7-((3R, 4S)-3-Amino-4-fluoromethylpyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione,
• 1-Cyclopropyl-7-[3(R)-(1-ethylaminoethyl)pyrrolidin-1-yl]-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione,
• 7-(3a-Aminomethyloctahydroisoindol-2-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione,
• 7-(3S, 4R)- and 7-((3R, 4S)-3-Amino-4-fluoromethylpyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione,
• 1-Cyclopropyl-7-[(R)-3-((S)-1-ethylaminoethyl)pyrrolidin-1-yl]-6-fluoro-8-methyl-1H-quinazoline-2,4-dione,
• 7-[(R)-3-((S)-1-Aminoethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione hydrochloride;
• or
• a pharmaceutically acceptable salt thereof.

The compound which is:

• 7-[3-Aminocyclopropyl)-4-trifluoromethylpyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(3-hydroxymethylpyrrolidin-1-yl)-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-8-methoxy-5-methyl-7-pyrrolidin-1-yl-1H-quinazoline-2,4-dione;
• 7-[3-Aminopyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(2-Amino-1-hydroxyethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(2-Amino-1-hydroxyethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-8-methoxy-5-methyl-7-morpholin-4-yl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-8-methoxy-5-methyl-7-piperazin-1-yl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-{3-[(2,4-difluorophenyl)hydroxymethyl]-4-fluoropyrrolidin-1-yl}-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-{3-[(4-fluorophenyl)hydroxymethyl]-4-fluoropyrrol idin-1-yl}-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(4-hydroxyoctahydroisoindol-2-yl)-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(4-hydroxyhexahydrocyclopent[c]pyrrol-2-yl)-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-aminocyclopropyl)-4-trifluoromethylpyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-7-(3-hydroxymethylpyrrolidin-1-yl)-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-8-methoxy-7-pyrrolidin-1-yl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-aminopyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(2-amino-1-hydroxyethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(2-amino-1-hydroxyethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-8-methoxy-7-morpholin-4-yl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-8-methoxy-7-piperazin-1-yl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-{3-[(2,4-difluorophenyl)hydroxymethyl]-4-fluoropyrrolidin-1-yl}-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-{3-[(4-fluorophenyl)hydroxymethyl]-4-fluoropyrrolidin-1-yl}-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-7-(4-hydroxyoctahydroisoindol-2-yl)-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-7-(4-hydroxyhexahydrocyclopent[c]pyrrol-2-yl)-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-Aminocyclopropyl)-4-trifluoromethylpyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(3-hydroxymethylpyrrolidin-1-yl)-5-hydroxy-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-5-hydroxy-8-methoxy-7-pyrrolidin-1-yl-1H-quinazoline-2,4-dione;
• 7-[3-Aminopyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(2-Amino-1-hydroxyethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(2-Amino-1-hydroxyethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-5-hydroxy-8-methoxy-7-morpholin-4-yl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-5-hydroxy-8-methoxy-7-piperazin-1-yl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-{3-[(2,4-difluorophenyl)hydroxymethyl]-4-fluoropyrrolidin-1-yl}-6-fluoro-5-hydroxy-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-{3-[(4-fluorophenyl)hydroxymethyl]-4-fluoropyrrolidin-1-yl}-6-fluoro-5-hydroxy-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(4-hydroxyoctahydroisoindol-2-yl)-5-hydroxy-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(4-hydroxyhexahydrocyclopent[c]pyrrol-2-yl)-5-hydroxy-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Aminocyclopropyl)-4-trifluoromethylpyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-7-(3-hydroxymethylpyrrolidin-1-yl)-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(3-Aminopyrrolidin-1-yl)-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-hydroxyethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-7-pyrrolidin-1-yl-1H-quinazoline-2,4-dione;
• 7-[3-(2-Amino-1-hydroxyethyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-7-piperazin-1-yl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-7-morpholin-4-yl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-di fluoromethyl-6-fluoro-7-{3-fluoro-4-[(4-fluorophenyl)-hydroxymethyl]pyrrolidin-1-yl}-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-7-{3-[(2,4-difluorophenyl)hydroxymethyl]-4-fluoropyrrolidin-1-yl}-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-7-(4-hydroxyoctahydroisoindol-2-yl)-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-7-(4-hydroxyhexahydro-cyclopenta[c]pyrrol-2-yl)-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(4-Aminooctahydrocyclohepta[c]pyrrol-2-yl)-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(3-hydroxymethylpyrrolidin-1-yl)-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 7-(3-Aminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-hydroxyethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-5,8-dimethyl-7-pyrrolidin-1-yl-1H-quinazoline-2,4-dione;
• 7-[3-(2-Amino-1-hydroxyethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-5,8-dimethyl-7-piperazin-1-yl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-5,8-dimethyl-7-morpholin-4-yl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-{3-fluoro-4-[(4-fluorophenyl)hydroxymethyl]-pyrrolidin-1-yl}-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-{3-[(2,4-difluorophenyl)hydroxymethyl]-4-fluoropyrrolidin-1-yl}-6-fluoro-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(4-hydroxyoctahydroisoindol-2-yl)-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(4-hydroxyhexahydrocyclopenta[c]pyrrol-2-yl)-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(4-hydroxyoctahydrocyclohepta[c]pyrrol-2-yl)-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Aminocyclopropyl)-4-trifluoromethylpyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(3-hydroxymethylpyrrolidin-1-yl)-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(3-Aminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-hydroxyethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-5-methoxy-8-methyl-7-pyrrolidin-1-yl-1H-quinazoline-2,4-dione;
• 7-[3-(2-Amino-1-hydroxyethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-5-methoxy-8-methyl-7-piperazin-1-yl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-5-methoxy-8-methyl-7-morpholin-4-yl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-{3-fluoro-4-[(4-fluorophenyl)hydroxymethyl]-pyrrolidin-1-yl}-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-{3-[(2,4-difluorophenyl)hydroxymethyl]-4-fluoropyrrolidin-1-yl}-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(4-hydroxy-octahydro-isoindol-2-yl)-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(4-hydroxyhexahydrocyclopenta[c]pyrrol-2-yl)-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(4-hydroxyoctahydrocyclohepta[c]pyrrol-2-yl)-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethylpyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Aminocyclopropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-1-methylethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-fluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2-difluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,2-trifluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Aminoethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 7-{3-[Amino-(2,6-difluorophenyl)methyl]pyrrolidin-1-yl}-1-cyclopropyl-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4-fluoromethylpyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(Aminothiazol-2-yl-methyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(Aminocyclopropylmethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 7-(4-Aminooctahydroisoindol-2-yl)-1-cyclopropyl-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 7-(4-Aminooctahydrocyclohepta[c]pyrrol-2-yl)-1-cyclopropyl-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-[3-(1-hydroxycyclopropyl)pyrrolidin-1-yl]-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 7-(4-Aminohexahydrocyclopenta[c]pyrrol-2-yl)-1-cyclopropyl-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(Aminooxazol-4-yl-methyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-(3-aminomethylpyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-aminocyclopropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-1-methylethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-2-fluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-2,2-difluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-2,2,2-trifluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-aminoethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-{3-[amino-(2,6-difluorophenyl)methyl]pyrrolidin-1-yl}-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-(3-aminomethyl-4-fluoromethylpyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(aminothiazol-2-yl-methyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(aminocyclopropylmethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-(4-aminooctahydroisoindol-2-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-(4-aminooctahydrocyclohepta[c]pyrrol-2-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-7-[3-(1-hydroxycyclopropyl)pyrrolidin-1-yl]-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-(4-aminohexahydrocyclopenta[c]pyrrol-2-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(aminooxazol-4-yl-methyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethylpyrrol idin-1-yl)-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Aminocyclopropyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-1-methylethyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-fluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2-difluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,2-trifluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-ethyl)-4-fluoro-pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-7-{3-[(2,6-difluorophenyl)hydroxymethyl]-pyrrolidin-1-yl}-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4-fluoromethylpyrrolidin-1-yl)-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(Aminothiazol-2-yl-methyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(Amino-cyclopropyl-methyl)-pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-7-[3-(1-hydroxycyclopropyl)-pyrrolidin-1-yl]-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(Aminooxazol-4-ylmethyl)pyrrolidin-1-yl]-1-cyclopropyl-5--difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethylpyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Aminocyclopropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-fluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2-difluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,2-trifluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-{3-[(2,6-difluorophenyl)hydroxymethyl]pyrrolidin-1-yl}-6-fluoro-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4-fluoromethylpyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 7-[3-(Aminothiazol-2-ylmethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 7-[3-(Aminocyclopropylmethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-[3-(1-hydroxycyclopropyl)pyrrolidin-1-yl]-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 7-[3-(Aminooxazol-4-ylmethyl)pyrrol idin-1-yl]-1-cyclopropyl-6-fluoro-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-(3-aminomethylpyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-aminocyclopropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-1-methylethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-2,2,2-trifluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-2-fluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-aminoethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-2,2-difluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-{3-[(2,6-difluorophenyl)hydroxymethyl]pyrrolidin-1-yl}-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-(3-aminomethyl-4-fluoromethylpyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(aminothiazol-2-ylmethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-7-[3-(1-hydroxycyclopropyl)pyrrolidin-1-yl]-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(aminooxazol-4-ylmethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-fluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2-difluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,2-trifluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(Aminothiazol-2-ylmethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-5-hydroxy-7-[3-(1-hydroxycyclopropyl)pyrrolidin-1-yl]-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(Aminooxazol-4-ylmethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Aminocyclopropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-fluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethylpyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2-difluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,2-trifluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Aminoethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-{3-[(2,6-difluorophenyl)hydroxymethyl]pyrrolidin-1-yl}-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4-fluoromethylpyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(Aminothiazol-2-ylmethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-[3-(1-hydroxycyclopropyl)pyrrolidin-1-yl]-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(Aminooxazol-4-ylmethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluorooctahydroisoindol-2-yl)-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluorohexahydrocyclopenta[c]pyrrol-2-yl)-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-(5,5-Difluoro-4-hydroxyoctahydroisoindol-2-yl)-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-(5,5-Difluoro-4-hydroxyhexahydrocyclopenta[c]pyrrol-2-yl)-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-hydroxyethyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3,3-trifluoro-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-(4-Aminomethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-7-(4-hydroxymethyl-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-8-methyl-1H-quinazoline-2,4-dione;
• 7-[4-(1-Aminoethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[4-(2-Amino-1-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-201-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[4-(1-Amino-2-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[4-(1-Amino-2,2,2-trifluoroethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-(5-Aminomethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-7-(5-hydroxymethyl-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-8-methyl-1H-quinazoline-2,4-dione;
• 7-[5-(1-Amino-2,2,2-trifluoroethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[5-(1-Aminoethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[5-(1-Amino-2-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4-trifluoromethylpyrrolidin-1-yl)-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,3,3,3-pentafluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3,3-trifluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3,3-trifluoro-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione
• 7-[4-(1-Aminoethyl)-3,3-difluoropyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-(3-Amino-4-ethylpiperidin-1-yl)-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-trifluoromethoxyethyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4-trifluoromethoxypyrrolidin-1-yl)-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-Aminomethyl-4-(2,2,2-trifluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoro-methyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione
• 7-[3-(1-Amino-2-difluoromethyl-3,3-difluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(-Amino-3-fluoro-2-fluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3-difluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(3,3-difluoro-4-hydroxymethylpyrrolidin-1-yl)-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-7-[7-(1,2-dihydroxyethyl)-5-azaspiro[2.4]hept-5-yl]-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(5,5-difluoro-4-hydroxymethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,2-trifluoro-1-trifluoromethylethyl)pyrrolidin-1-yl-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-Aminomethyl-4-(3,3,3-trifluoro-2-trifluoromethylpropyl)pyffolidin-1-yl]-1-cyclopropyl-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-4,4,4-trifluoro-3-trifluoromethylbut-2-enyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-4,4,4-trifluoro-3-trifluoromethylbutyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-hydroxyethyl)-4-fluoropyrrolidin-1-yl-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,2-trifluoroethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4-difluoromethoxypyrrolidin-1-yl)-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-(4-Aminomethyl-5,5-difluoro-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluorooctahydrocyclohepta[c]pyrrol-2-yl)-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(5,5-difluoro-4-hydroxyoctahydrocyclohepta[c]pyrrol-2-yl)-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[5-(1-Aminoethyl)thiophen-3-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-(5-Aminomethylthiophen-3-yl)-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluoro-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(5,5-difluoro-4-hydroxy-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluorooctahydroisoindol-2-yl)-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluorohexahydrocyclopenta[c]pyrrol-2-yl)-1-cyclopropyl-5-difluoro-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(5,5-difluoro-4-hydroxyhexahydrocyclopenta[c]pyrrol-2-yl)-5-difluoro-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-hydroxyethyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(5,5-difluoro-4-hydroxyoctahydroisoindol-2-yl)-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-hydroxyethyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3,3-trifluoro-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(4-Aminomethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-7-(4-hydroxymethyl-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-8-methooxy-1H-quinazoline-2,4-dione;
• 7-[4-(1-Aminoethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[4-(2-Amino-1-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[4-(1-Amino-2-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-y]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[4-(-Amino-2,2,2-trifluoroethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione
• 7-(5-Aminomethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-7-(5-hydroxymethyl-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[5-(1-Amino-2,2,2-trifluoroethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione
• 7-[5-(1-Aminoethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[5-(1-Amino-2-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[5-(2-Amino-1-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4-trifluoromethylpyrrolidin-1-yl)-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,3,3,3-pentafluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[4-(1-Aminoethyl)-3,3-difluoropyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(3-Amino-4-ethylpiperidin-1-yl)-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-trifluoromethoxyethyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4-trifluoromethoxypyrrolidin-1-yl)-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-Aminomethyl-4-(2,2,2-trifluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoro-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-difluoromethyl-3,3-difluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3-fluoro-2-fluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3-difluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(3,3-difluoro-4-hydroxymethylpyrrolidin-1-yl)-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-7-[7-(1,2-dihydroxyethyl)-5-azaspiro[2.4]hept-5-yl]-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(5,5-difluoro-4-hydroxymethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,2-trifluoro-1-trifluoromethylethyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-Aminomethyl-4-(3,3,3-trifluoro-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-4,4,4-trifluoro-3-trifluoromethylbut-2-enyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-4,4,4-trifluoro-3-trifluoromethylbutyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-hydroxyethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,2-trifluoroethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4-difluoromethoxypyrrolidin-1-yl)-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(4-Aminomethyl-5,5-difluoro-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluorooctahydrocyclohepta[c]pyrrol-2-yl)-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(5,5-difluoro-4-hydroxyoctahydrocyclohepta[c]pyrrol-2-yl)-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[5-(1-Aminoethyl)thiophen-3-yl]-]-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(5-Aminomethylthiophen-3-yl)-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluoro-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(5,5-difluoro-4-hydroxy-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluorooctahydroisoindol-2-yl)-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluorohexahydrocyclopenta[c]pyrrol-2-yl)-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-(5,5-Difluoro-4-hydroxyoctahydroisoindol-2-yl)-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-(5,5-Difluoro-4-hydroxyhexahydrocyclopenta[c]pyrrol-2-yl)-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-hydroxyethyl)pyrrolidin-1-yl]-1-cyclopropyl-5-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3,3-trifluoro-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-5,8-dimethyl-6-fluoro-]1H-quinazoline-2,4-dione;
• 7-(4-Aminomethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5,8-dimethyl-6-fluoro-7-(4-hydroxymethyl-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-1H-quinazoline-2,4-dione;
• 7-[4-(1-Aminoethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-[4-(2-Amino-1-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-[4-(1-Amino-2-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-[4-(1-Amino-2,2,2-trifluoroethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-(5-Aminomethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5,8-dimethyl-6-fluoro-7-(5-hydroxymethyl-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-1H-quinazoline-2,4-dione;
• 7-[5-(1-Amino-2,2,2-trifluoroethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-5,8-methyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4-trifluoromethylpyrrolidin-1-yl)-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,3,3,3-pentafluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3,3-trifluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3,3-trifluoro-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4-trifluoromethylpyrrolidin-1-yl)-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,3,3,3-pentafluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3,3-trifluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-[4-(1-Aminoethyl)-3,3-difluoropyrrolidin-1-yl]-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-(3-Amino-4-ethylpiperidin-1-yl)-1-cyclopropyl-5,8-dimethyl-6-fluoro-8-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-trifluoromethoxyethyl)pyrrolidin-1-yl]-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4-trifluoromethoxypyrrolidin-1-yl)-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-[3-Aminomethyl-4-(2,2,2-trifluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione
• 7-[3-(1-Amino-2,2-difluoromethyl-3,3-difluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3-fluoro-2-fluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3-difluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(3,3-difluoro-4-hydroxymethylpyrrolidin-1-yl)-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5,8-dimethyl-7-[7-(1,2-dihydroxyethyl)-5-azaspiro[2.4]hept-5-yl]-6-fluoro-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(5,5-difluoro-4-hydroxymethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,2-trifluoro-1,1,1-trifluoromethylethyl)pyrrolidin-1-yl]-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-[3-Aminomethyl-4-(3,3,3-trifluoro-2,2,2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-4,4,4-trifluoro-3,3,-trifluoromethylbut-2-enyl)pyrrolidin-1-yl]-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-4,4,4-trifluoro-3,3,3-trifluoromethylbutyl)pyrrolidin-1-yl]-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-hydroxyethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,2-trifluoroethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4,4-difluoromethoxypyrrolidin-1-yl)-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-(4-Aminomethyl-5,5-difluoro-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluorooctahydrocyclohepta[c]pyrrol-2-yl)-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(5,5-difluoro-4-hydroxyoctahydrocyclohepta[c]pyrrol-2-yl)-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-[5-(1-Aminoethyl)thiophen-3-yl]-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-(5-Aminomethylthiophen-3-yl)-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluoro-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(5,5-difluoro-4-hydroxy-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-5,8-dimethyl-6-fluoro-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluorooctahydroisoindol-2-yl)-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluorohexahydrocyclopenta[c]pyrrol-2-yl)-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(5,5-Difluoro-4-hydroxyoctahydroisoindol-2-yl)-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(5,5-Difluoro-4-hydroxyhexahydrocyclopenta[c]pyrrol-2-yl)-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-hydroxyethyl)pyrrolidin-1-yl]-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3,3-trifluoro-2,2,2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(4-Aminomethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-methyl-6-fluoro-7-(4-hydroxymethyl-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[4-(1-Aminoethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[4-(2-Amino-1-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[4-(1-Amino-2-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[4-(1-Amino-2,2,2-trifluoroethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-5-methyl-6-fluoro-8-methxoy-1H-quinazoline-2,4-dione;
• 7-(5-Aminomethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-methyl-6-fluoro-7-(5-hydroxymethyl-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[5-(1-Amino-2,2,2-trifluoroethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4-trifluoromethylpyrrolidin-1-yl)-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,3,3,3-pentafluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3,3-trifluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3,3-trifluoro-2,2,2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4,4,4-trifluoromethylpyrrolidin-1-yl)-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,3,3,3-pentafluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3,3-trifluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4-trifluoromethylpyrrolidin-1-yl)-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,3,3,3-pentafluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3,3-trifluoropropyl)pyrrolidin-1-yl-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[4-(1-Aminoethyl)-3,3-difluoropyrrolidin-1-yl]-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(3-Amino-4-ethylpiperidin-1-yl)-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-trifluoromethoxyethyl)pyrrolidin-1-yl]-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4,4,4-trifluoromethoxypyrrolidin-1-yl)-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-Aminomethyl-4-(2,2,2-trifluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2-difluoromethyl-3,3-difluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3-fluoro-2-fluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3-difluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(3,3-difluoro-4-hydroxymethylpyrrolidin-1-yl)-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-methyl-7-[7-(,2-dihydroxyethyl)-5-azaspiro[2.4]hept-5-yl]-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(5,5-difluoro-4-hydroxymethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,2-trifluoro-1,1,1-trifluoromethylethyl)pyrrolidin-1-yl]-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-Aminomethyl-4-(3,3,3-trifluoro-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-4,4,4-trifluoro-3,3,3-trifluoromethylbut-2-enyl)pyrrolidin-1-yl]-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-4,4,4-trifluoro-3,3,3-trifluoromethylbutyl)pyrrolidin-1-yl]-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-hydroxyethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,2-trifluoroethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4,4-difluoromethoxypyrrolidin-1-yl)-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(4-Aminomethy]-5,5-difluoro-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluorooctahydrocyclohepta[c]pyrrol-2-yl)-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(5,5-difluoro-4-hydroxyoctahydrocyclohepta[c]pyrrol-2-yl)-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[5-(1-Aminoethyl)thiophen-3-yl]-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(5-Aminomethylthiophen-3-yl)-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluoro-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(5,5-difluoro-4-hydroxy-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-5-methyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-(4-amino-5,5-difluorooctahydroisoindol-2-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-(4-amino-5,5-difluorohexahydrocyclopenta[c]pyrrol-2-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-(5,5-difluoro-4-hydroxyoctahydroisoindol-2-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-(5,5-difluoro-4-hydroxyhexahydrocyclopenta[c]pyrrol-2-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-2-hydroxyethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-3,3,3-trifluoro-2,2,2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-(4-aminomethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-7-(4-hydroxymethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[4-(1-aminoethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[4-(2-amino-1-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[4-(1-amino-2-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[4-(1-amino-2,2,2-trifluoroethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-(5-aminomethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-7-(5-hydroxymethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[5-(1-amino-2,2,2-trifluoroethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-(3-aminomethyl-4-trifluoromethylpyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-2,2,3,3,3-pentafluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-3,3,3-trifluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-3,3,3-trifluoro-2,2,2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-(3-aminomethyl-4-trifluoromethylpyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-2,2,3,3,3-pentafluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-3-trifluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-3,3,3-trifluoro-2,2,2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[4-(1-aminoethyl)-3,3-difluoropyrrolidin-1-yl-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-(3-amino-4-ethylpiperidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-2,2,2-trifluoromethoxyethyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-(3-aminomethyl-4-trifluoromethoxypyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-aminomethyl-4-(2,2,2-trifluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-2-difluoromethyl-3,3-difluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-3-fluoro-2-fluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-3,3-difluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-(3,3-difluoro-4-hydroxymethylpyrrolidin-1-yl)-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-[7-(1,2-dihydroxyethyl)-5-azaspiro[2.4]hept-5-yl]-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-(5,5-difluoro-4-hydroxymethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-2,2,2-trifluoro-1-trifluoromethylethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-aminomethyl-4-(3,3,3-trifluoro-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-4,4,4-trifluoro-3-trifluoromethyl-but-2-enyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-4,4,4-trifluoro-3-trifluoromethylbutyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-2-hydroxyethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-2,2,2-trifluoroethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-(3-aminomethyl-4-difluoromethoxypyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-(4-aminomethyl-5,5-difluoro-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-(4-amino-5,5-difluorooctahydrocyclohepta[c]pyrrol-2-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-(5,5-difluoro-4-hydroxyoctahydrocyclohepta[c]pyrrol-2-yl)-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[5-(1-aminoethyl)thiophen-3-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-(5-aminomethylthiophen-3-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-(4-amino-5,5-difluoro-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-(5,5-difluoro-4-hydroxy-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-(4-amino-5,5-difluorooctahydroisoindol-2-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-(4-amino-5,5-difluorohexahydrocyclopenta[c]pyrrol-2-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-(5,5-difluoro-4-hydroxyoctahydroisoindol-2-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-(5,5-difluoro-4-hydroxyhexahydrocyclopenta[c]pyrrol-2-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-2-hydroxyethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-3,3,3-trifluoro-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-(4-aminomethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-7-(4-hydroxymethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[4-(1-aminoethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[4-(2-amino-]-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[4-(1-amino-2-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[4-(1-amino-2,2,2-trifluoroethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-(5-aminomethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-7-(5-hydroxymethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[5-(1-amino-2,2,2-trifluoroethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amiino-7-(3-aminomethyl-4-trifluoromethylpyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-2,2,3,3,3-pentafluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-3,3,3-trifluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-3,3,3-trifluoro-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-(3-aminomethyl-4-trifluoromethylpyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-2,2,3,3,3-pentafluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-3,3,3-trifluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-3,3,3-trifluoro-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[4-(1-aminoethyl)-3,3-difluoropyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-(3-amino-4-ethylpiperidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-2-trifluoromethoxyethyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-(3-aminomethyl-4-trifluoromethoxypyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-aminomethyl-4-(2,2,2-trifluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-2-difluoromethyl-3,3-difluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(-amino-3-fluoro-2-fluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-3,3-difluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-(3,3-difluoro-4-hydroxymethylpyrrolidin-1-yl)-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-[7-(1,2-dihydroxyethyl)-5-azaspiro[2.4]hept-5-yl]-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-(5,5-difluoro-4-hydroxymethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-2,2,2-trifluoro-1-trifluoromethylethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-aminomethyl-4-(3,3,3-trifluoro-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-4,4,4-trifluoro-3-trifluoromethyl-but-2-enyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-4,4,4-trifluoro-3-trifluoromethylbutyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-2-hydroxyethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-2,2,2-trifluoroethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-(3-aminomethyl-4-difluoromethoxypyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-(4-aminomethyl-5,5-difluoro-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-(4-amino-5,5-difluorooctahydrocyclohepta[c]pyrrol-2-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-(5,5-difluoro-4-hydroxyoctahydrocyclohepta[c]pyrrol-2-yl)-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[5-(1-aminoethyl)thiophen-3-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-(5-aminomethylthiophen-3-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-(4-amino-5,5-difluoro-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-(5,5-difluoro-4-hydroxy-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluorooctahydroisoindol-2-yl)-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluorohexahydrocyclopenta[c]pyrrol-2-yl)-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(5,5-Difluoro-4-hydroxyoctahydroisoindol-2-yl)-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(5,5-Difluoro-4-hydroxyhexahydrocyclopenta[c]pyrrol-2-yl)-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-hydroxyethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3,3-trifluoro-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(4-Aminomethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(4-hydroxymethyl-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[4-(1-Aminoethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[4-(2-Amino-1-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[4-(1-Amino-2-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[4-(1-Amino-2,2,2-trifluoroethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(5-Aminomethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(5-hydroxymethyl-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[5-(1-Amino-2,2,2-trifluoroethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[5-(1-Aminoethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[5-(1-Amino-2-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4-trifluoromethylpyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,3,3,3-pentafluoropropyl)pyrrolidin-1-yl]-1-cyclopropy-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3,3-trifluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3,3-trifluoro-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[4-(1-Aminoethyl)-3,3-difluoropyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(3-Amino-4-ethylpiperidin-1-yl)-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-trifluoromethoxyethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4-trifluoromethoxypyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-Aminomethyl-4-(2,2,2-trifluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-difluoromethyl-3,3-difluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3-fluoro-2-fluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3-difluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(3,3-difluoro-4-hydroxymethylpyrrolidin-1-yl)-6-fluoro-5-hydroxy-8-methyl-1H -quinazoline-2,4-dione;
• 1-Cyclopropyl-7-[7-(1,2-dihydroxyethyl)-5-azaspiro[2.4]hept-5-yl]-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(5,5-difluoro-4-hydroxymethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,2-trifluoro-1-trifluoromethylethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-Aminomethyl-4-(3,3,3-trifluoro-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-4,4,4-trifluoro-3-trifluoromethylbut-2-enyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-4,4,4-trifluoro-3-trifluoromethylbutyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-hydroxyethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,2-trifluoroethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4-difluoromethoxypyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(4-Aminomethyl-5,5-difluoro-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluorooctahydrocyclohepta[c]pyrrol-2-yl)-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(5,5-difluoro-4-hydroxyoctahydrocyclohepta[c]pyrrol-2-yl)-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[5-(1-Aminoethyl)thiophen-3-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(5-Aminomethylthiophen-3-yl)-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluoro-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(5,5-difluoro-4-hydroxy-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluorooctahydroisoindol-2-yl)-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluorohexahydrocyclopenta[c]pyrrol-2-yl)-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(5,5-Difluoro-4-hydroxyoctahydroisoindol-2-yl)-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(5,5-Difluoro-4-hydroxyhexahydrocyclopenta[c]pyrrol2-yl)-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-hydroxyethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3,3-trifluoro-2-trifluoromethylpropyl)pyrrolidin-1-yl]-]-cyclopropyl-6-fluoro-5-emthoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(4-Aminomethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(4-hydroxymethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[4-(1-Aminoethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[4-(2-Amino-1-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[4-(1-Amino-2-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[4-(1-Amino-2,2,2-trifluoroethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1′-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(5-Aminomethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(5-hydroxymethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[5-(-Amino-2,2,2-trifluoroethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[5-(1-Aminoethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[5-(1-Amino-2-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4-trifluoromethylpyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,3,3,3-pentafluoropropyl)pyrrolidin-1-yl]-1-cyclopropy-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3,3-trifluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3,3-trifluoro-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[4-(1-Aminoethyl)-3,3-difluoropyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(3-Amino-4-ethylpiperidin-1-yl)-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-trifluoromethoxyethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4-trifluoromethoxypyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-Aminomethyl-4-(2,2,2-trifluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-difluoromethyl-3,3-difluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3-fluoro-2-fluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3-difluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(3,3-difluoro-4-hydroxymethylpyrrolidin-1-yl)-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-[7-(1,2-dihydroxyethyl)-5-azaspiro[2.4]hept-5-yl]-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(5,5-difluoro-4-hydroxymethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,2-trifluoro-1-trifluoromethylethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluor6-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-Aminomethyl-4-(3,3,3-trifluoro-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-4,4,4-trifluoro-3-trifluoromethyl-but-2-enyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-4,4,4-trifluoro-3-trifluoromethylbutyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-hydroxyethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,2-trifluoroethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4-difluoromethoxypyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(4-Aminomethyl-5,5-difluoro-4,5,6,7-tetrahydrobenzo[b]thlophen-2-yl)-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluorooctahydrocyclohepta[c]pyrrol-2-yl)-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(5,5-difluoro-4-hydroxyoctahydrocyclohepta[c]pyrrol-2-yl)-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-[5-(1-Aminoethyl)thiophen-3-yl]-1-cyclopropyl-6-fluoro-5-hydroxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(5-Aminomethylthiophen-3-yl)-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluoro-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(5,5-difluoro-4-hydroxy-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-6-fluoro-5-methoxy-8-methyl-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluorooctahydroisoindol-2-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluorohexahydrocyclopenta[c]pyrrol-2-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-(5,5-Difluoro-4-hydroxyoctahydroisoindol-2-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-(5,5-Difluoro-4-hydroxyhexahydrocyclopenta[c]pyrrol-2-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-hydroxyethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3,3-trifluoro-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-(4-Aminomethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(4-hydroxymethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-8-methyl-1H-quinazoline-2,4-dione;
• 7-[4-(1-Aminoethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[4-(2-Amino-1-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-251-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[4-(1-Amino-2-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-y]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[4-(1-Amino-2,2,2-trifluoroethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-(5-Aminomethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(5-hydroxymethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-8-methyl-1H-quinazoline-2,4-dione;
• 7-[5-(1-Amino-2,2,2-trifluoroethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[5-(1-Aminoethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[5-(1-Amino-2-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4-trifluoromethylpyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,3,3,3-pentafluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3,3-trifluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3,3-trifluoro-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[4-(1-Aminoethyl)-3,3-difluoropyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-(3-Amino-4-ethylpiperidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-trifluoromethoxyethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4-trifluoromethoxypyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-Aminomethyl-4-(2,2,2-trifluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-difluoromethyl-3,3-difluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3-fluoro-2-fluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione
• 7-[3-(1-Amino-3,3-difluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(3,3-difluoro-4-hydroxymethylpyrrolidin-1-yl)-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-[7-(1,2-dihydroxyethyl)-5-azaspiro[2.4]hept-5-yl]-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(5,5-difluoro-4-hydroxymethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,2-trifluoro-1-trifluoromethylethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-Aminomethyl-4-(3,3,3-trifluoro-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-4,4,4-trifluoro-3-trifluoromethyl-but-2-enyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-4,4,4-trifluoro-3-trifluoromethylbutyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-hydroxyethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,2-trifluoroethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4-difluoromethoxypyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-(4-Aminomethyl-5,5-difluoro-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluorooctahydrocyclohepta[c]pyrrol-2-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(5,5-difluoro-4-hydroxyoctahydrocyclohepta[c]pyrrol-2-yl)-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[5-(1-Aminoethyl)thiophen-3-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-(5-Aminomethylthiophen-3-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluoro-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione
• 1-Cyclopropyl-7-(5,5-difluoro-4-hydroxy-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-6-fluoro-8-methyl-1H-quinazoline-2,4-dione
• 7-(4-Amino-5,5-difluorooctahydroisoindol-2-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluorohexahydrocyclopenta[c]pyrrol-2-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(5,5-Difluoro-4-hydroxyoctahydroisoindol-2-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(5,5-Difluoro-4-hydroxyhexahydrocyclopenta[c]pyrrol-2-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-hydroxyethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3,3-trifluoro-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(4-Aminomethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(4-hydroxymethyl-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[4-(1-Aminoethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[4-(2-Amino-1-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[4-(1-Amino-2-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[4-(1-Amino-2,2,2-trifluoroethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(5-Aminomethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(5-hydroxymethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-8-methoxy-1H-quinazoine-2,4-dione;
• 7-[5-(1-Amino-2,2,2-trifluoroethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[5-(1-Aminoethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[5-(1-Amino-2-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4-trifluoromethylpyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,3,3,3-pentafluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3,3-trifluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3,3-trifluoro-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[4-(1-Aminoethyl)-3,3-difluoropyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(3-Amino-4-ethylpiperidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-trifluoromethoxyethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4-trifluoromethoxypyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-Aminomethyl-4-(2,2,2-trifluoroethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-difluoromethyl-3,3-difluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3-fluoro-2-fluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3-difluoropropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(3,3-difluoro-4-hydroxymethylpyrrolidin-1-yl)-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-[7-(1,2-dihydroxyethyl)-5-azaspiro[2.4]hept-5-yl]-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(5,5-difluoro-4-hydroxymethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,2-trifluoro-1-trifluoromethylethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-Aminomethyl-4-(3,3,3-trifluoro-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-4,4,4-trifluoro-3-trifluoromethylbut-2-enyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-4,4,4-trifluoro-3-trifluoromethylbutyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-hydroxyethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2,2,2-trifluoroethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(3-Aminomethyl-4-difluoromethoxypyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(4-Aminomethyl-5,5-difluoro-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluorooctahydrocyclohepta[c]pyrrol-2-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(5,5-difluoro-4-hydroxyoctahydrocyclohepta[c]pyrrol-2-yl)-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[5-(1-Aminoethyl)thiophen-3-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(5-Aminomethylthiophen-3-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-(4-Amino-5,5-difluoro-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(5,5-difluoro-4-hydroxy-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-[3-(1,2-dihydroxy-2-methylpropyl)pyrrolidin-1-yl]-6-fluoro-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-5,8-dimethyl-7-[3-(3,3,3-trifluoro-1,2-dihydroxy-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-{3-[hydroxy(1-hydroxycyclopropyl)methyl]pyrrolidin-1-yl}-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-{3-[hydroxy(1-hydroxycyclopentyl)methyl]pyrrolidin-1-yl}-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-hydroxy-2-methylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3,3-trifluoro-2-hydroxy-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 7-{3-[Amino-(1-hydroxycyclopropyl)methyl]pyrrolidin-1-yl}-1-cyclopropyl-6-fluoro-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 7-{3-[Amino-(1-hydroxycyclopentyl)methyl]pyrrolidin-1-yl}-1-cyclopropyl-6-fluoro-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(4,5-dihydroxyhexahydrocyclopenta[c]pyrrol-2-yl)-6-fluoro-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(4,5-dihydroxyoctahydroisoindol-2-yl)-6-fluoro-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(4,5-dihydroxyoctahydrocyclohepta[c]pyrrol-2-yl)-6-fluoro-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(4,5-dihydroxydecahydrocycloocta[c]pyrrol-2-yl)-6-fluoro-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-[3-(1,2-dihydroxy-2-methylpropyl)pyrrolidin-1-yl]-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-8-methyl-7-[3-(3,3,3-trifluoro-1,2-dihydroxy-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-7-{3-[hydroxy-(1-hydroxycyclopropyl)methyl]pyrrolidin-1-yl}-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-7-{3-[hydroxy-(1-hydroxycyclopentyl)methyl]pyrrolidin-1-yl}-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-2-hydroxy-2-methylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-3,3,3-trifluoro-2-hydroxy-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-{3-[amino-(1-hydroxycyclopropyl)methyl]pyrrolidin-1-yl}-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-7-{3-[amino-(1-hydroxycyclopentyl)methyl]pyrrolidin-1-yl}-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-(4,5-dihydroxyhexahydrocyclopenta[c]pyrrol-2-yl)-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-(4,5-dihydroxyoctahydroisoindol-2-yl)-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-(4,5-dihydroxyoctahydrocyclohepta[c]pyrrol-2-yl)-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-(4,5-dihydroxydecahydrocycloocta[c]pyrrol-2-yl)-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-7-[3-(1,2-dihydroxy-2-methylpropyl)pyrrolidin-1-yl]-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-7-[3-(3,3,3-trifluoro-1,2-dihydroxy-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-7-{3-[hydroxy-(1-hydroxycyclopropyl)methyl]pyrrolidin-1-yl}-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-7-{3-[hydroxy-(1-hydroxycyclopentyl)methyl]pyrrolidin-1-yl}-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-hydroxy-2-methylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3,3-trifluoro-2-hydroxy-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-{3-[Amino-(1-hydroxycyclopropyl)methyl]pyrrolidin-1-yl}-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 7-{3-[Amino-(1-hydroxycyclopentyl)methyl]pyrrolidin-1-yl}-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-7-(4,5-dihydroxyhexahydrocyclopenta[c]pyrrol-2-yl)-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-7-(4,5-dihydroxyoctahydroisoindol-2-yl)-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-7-(4,5-dihydroxyoctahydrocyclohepta[c]pyrrol-2-yl)-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-7-(4,5-dihydroxydecahydrocycloocta[c]pyrrol-2-yl)-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(3-fluoro-4-hydroxymethylpyrrolidin-1-yl)-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(3,4-dihydroxypiperidin-1-yl)-6-fluoro-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(3-hydroxymethyl-4-methylpiperidin-1-yl)-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-[3-(1,2-dihydroxy-2-methylpropyl)-4-fluoropyrrolidin-1-yl]-6-fluoro-5,8-di methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-{3-fluoro-4-[hydroxy-(1-hydroxycyclopropyl)methyl]pyrrolidin-1-yl}-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-{3-fluoro-4-[hydroxy-(1-hydroxycyclopentyl)methyl]pyrrolidin-1-yl}-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-[3-fluoro-4-(3,3,3-trifluoro-1,2-dihydroxy-2-trifluoromethylpropyl)pyrrolidin-1-yl]-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(4-ethyl-3-hydroxypiperidin-1-yl)-6-fluoro-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(4-ethyl-3-hydroxymethylpiperidin-1-yl)-6-fluoro-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(3-hydroxy-4-methylpiperidin-1-yl)-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-5,8-dimethyl-7-[3-(2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl]-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-[3-(1,2-dihydroxyethyl)-4-fluoropyrrolidin-1-yl]-6-fluoro-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(4-hydroxy-3-hydroxymethylpiperidin-1-yl)-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-7-(3-fluoro-4-hydroxymethylpyrrolidin-1-yl)-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-[3-(1,2-dihydroxyethyl)-4-fluoropyrrolidin-1-yl]-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-8-methyl-7-[3-(2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl]-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-(3,4-dihydroxypiperidin-1-yl)-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(4-hydroxy-3-hydroxymethylpiperidin-1-yl)-5,8-dimethyl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-7-(3-hydroxymethyl-4-methylpiperidin-1-yl)-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-[3-(1,2-dihydroxy-2-methylpropyl)-4-fluoropyrrolidin-1-yl]-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-7-{3-fluoro-4-[hydroxy-(1-hydroxycyclopropyl)methyl]pyrrolidin-1-yl}-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-7-(3-hydroxy-4-methylpiperidin-1-yl)-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-(4-ethyl-3-hydroxypiperidin-1-yl)-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-(4-ethyl-3-hydroxymethylpiperidin-1-yl)-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-7-[3-fluoro-4-(3,3,3-trifluoro-1,2-dihydroxy-2-trifluoromethylpropyl)pyrrolidin-1-yl]-8-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-7-{3-fluoro-4-[hydroxy-(1-hydroxycyclopentyl)methyl]pyrrolidin-1-yl}-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-7-{3-fluoro-4-[hydroxy-(1-hydroxycyclopropyl)methyl]pyrrolidin-1-yl}-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-7-[3-(1,2-dihydroxy-2-methylpropyl)-4-fluoropyrrolidin-1-yl]-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-7-(3-hydroxymethyl-4-methylpiperidin-1-yl)-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-7-(3,4-dihydroxypiperidin-1-yl)-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-7-(3-fluoro-4-hydroxymethylpyrrolidin-1-yl)-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-7-{3-fluoro-4-[hydroxy-(1-hydroxycyclopentyl)methyl]pyrrolidin-1-yl}-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-7-[3-fluoro-4-(3,3,3-trifluoro-1,2-dihydroxy-2-trifluoromethylpropyl) pyrrolidin-1-yl]-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-7-(4-ethyl-3-hydroxymethylpiperidin-1-yl)-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-7-(4-ethyl-3-hydroxypiperidin-1-yl)-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-7-(4-hydroxy-3-hydroxymethylpiperidin-1-yl)-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-7-(3-hydroxy-4-methylpiperidin-1-yl)-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-7-[3-(1,2-dihydroxyethyl)-4-fluoropyrrolidin-1-yl]-6-fluoro-8-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-8-methyl-7-[3-(2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl]-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-[3-(1,2-dihydroxy-2-methylpropyl)-pyrrolidin-1-yl]-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-8-methoxy-5-methyl-7-[3-(3,3,3-trifluoro-1,2-dihydroxy-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-{3-[hydroxy-(1-hydroxycyclopropyl)methyl]-pyrrolidin-1-yl}-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-{3-[hydroxy-(1-hydroxycyclopentyl)-methyl]pyrrolidin-1-yl}-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-hydroxy-2-methylpropyl)-pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3,3-trifluoro-2-hydroxy-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 7-{3-[Amino-(1-hydroxycyclopropyl)methyl]pyrrolidin-1-yl}-1-cyclopropyl-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 7-{3-[Amino-(1-hydroxycyclopentyl)methyl]pyrrolidin-1-yl}-1-cyclopropyl-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(4,5-dihydroxyhexahydrocyclopenta[c]pyrrol-2-yl)-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(4,5-dihydroxyoctahydroisoindol-2-yl)-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(4,5-dihydroxyoctahydrocyclohepta[c]pyrrol-2-yl)-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(4,5-dihydroxydecahydrocycloocta[c]pyrrol-2-yl)-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-[3-(1,2-dihydroxy-2-methylpropyl)pyrrolidin-1-yl]-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-8-methoxy-7-[3-(3,3,3-trifluoro-1,2-dihydroxy-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-7-{3-[hydroxy-(1-hydroxycyclopropyl)methyl]-pyrrolidin-1-yl}-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-7-{3-[hydroxy-(1-hydroxycyclopentyl)methyl]-pyrrolidin-1-yl}-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-2-hydroxy-2-methylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-[3-(1-amino-3,3,3-trifluoro-2-hydroxy-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-{3-[amino-(1-hydroxycyclopropyl)methyl]pyrrolidin-1-yl}-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-7-{3-[amino-(1-hydroxycyclopentyl)methyl]pyrrolidin-1-yl}-1-cyclopropyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-(4,5-dihydroxyhexahydrocyclopenta[c]pyrrol-2-yl)-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-(4,5-dihydroxyoctahydroisoindol-2-yl)-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-(4,5-dihydroxyoctahydrocyclohepta[c]pyrrol-2-yl)-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-(4,5-dihydroxydecahydrocycloocta[c]pyrrol-2-yl)-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-7-[3-(1,2-dihydroxy-2-methylpropyl)pyrrolidin-1-yl]-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-7-[3-(3,3,3-trifluoro-1,2-dihydroxy-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-7-{3-[hydroxy-(1-hydroxy-cyclopropyl)methyl]pyrrolidin-1-yl}-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-7-{3-[hydroxy-(1-hydroxycyclopentyl)methyl]pyrrolidin-1-yl}-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-2-hydroxy-2-methylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-[3-(1-Amino-3,3,3-trifluoro-2-hydroxy-2-trifluoromethylpropyl)pyrrolidin-1-yl]-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-{3-[Amino-(1-hydroxycyclopropyl)methyl]pyrrolidin-1-yl}-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 7-{3-[Amino-(1-hydroxycyclopentyl)methyl]pyrrolidin-1-yl}-1-cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-7-(4,5-dihydroxyhexahydrocyclopenta[c]pyrrol-2-yl)-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-7-(4,5-dihydroxyoctahydroisoindol-2-yl)-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-7-(4,5-dihydroxyoctahydrocyclohepta[c]pyrrol-2-yl)-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-7-(4,5-dihydroxydecahydrocycloocta[c]pyrrol-2-yl)-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(3-fluoro-4-hydroxymethylpyrrolidin-1-yl)-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-[3-(1,2-dihydroxyethyl)-4-fluoropyrrolidin-1-yl]-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-8-methoxy-5-methyl-7-[3-(2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl]-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(3,4-dihydroxypiperidin-1-yl)-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(4-hydroxy-3-hydroxymethylpiperidin-1-yl)-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(3-hydroxy-4-methylpiperidin-1-yl)-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-(3-hydroxymethyl-4-methylpiperidin-1-yl)-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(4-ethyl-3-hydroxymethylpiperidin-1-yl)-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-(4-ethyl-3-hydroxypiperidin-1-yl)-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-7-[3-(1,2-dihydroxy-2-methylpropyl)-4-fluoropyrrolidin-1-yl]-6-fluoro-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-[3-fluoro-4-(3,3,3-trifluoro-1,2-dihydroxy-2-trifluoromethylpropyl)-pyrrolidin-1-yl]-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-{3-fluoro-4-[hydroxy-(1-hydroxycyclopropyl)methyl]-pyrrolidin-1-yl}-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-6-fluoro-7-{3-fluoro-4-[hydroxy-(1-hydroxycyclopentyl)methyl]pyrrolidin-1-yl}-8-methoxy-5-methyl-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-7-(3-fluoro-4-hydroxymethylpyrrolidin-1-yl)-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-[3-(1,2-dihydroxyethyl)-4-fluoropyrrolidin-1-yl]-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-8-methoxy-7-[3-(2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl]-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-(3,4-dihydroxypiperidin-1-yl)-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-7-(4-hydroxy-3-hydroxymethylpiperidin-1-yl)-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-7-(3-hydroxy-4-methylpiperidin-1-yl)-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-7-(3-hydroxymethyl-4-methylpiperidin-1-yl)-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-(4-ethyl-3-hydroxymethylpiperidin-1-yl)-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-(4-ethyl-3-hydroxypiperidin-1-yl)-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-7-[3-(1,2-dihydroxy-2-methylpropyl)-4-fluoropyrrolidin-1-yl]-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-7-[3-fluoro-4-(3,3,3-trifluoro-1,2-dihydroxy-2-trifluoromethylpropyl)pyrrolidin-1-yl]-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-7-{3-fluoro-4-[hydroxy-(1-hydroxycyclopropyl)methyl]pyrrolidin-1-yl}-8-methoxy-1H-quinazoline-2,4-dione;
• 5-Amino-1-cyclopropyl-6-fluoro-7-{3-fluoro-4-[hydroxy-(1-hydroxycyclopentyl)methyl]pyrrolidin-1-yl}-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-7-(3-fluoro-4-hydroxymethylpyrrolidin-1-yl)-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-7-[3-(1,2-dihydroxyethyl)-4-fluoropyrrolidin-1-yl]-6-fluoro-8-methoxy-1 H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-8-methoxy-7-[3-(2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl]-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-7-(3,4-dihydroxypiperidin-1-yl)-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-7-(4-hydroxy-3-hydroxymethylpiperidin-1-yl)-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-7-(3-hydroxy-4-methylpiperidin-1-yl)-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-7-(3-hydroxymethyl-4-methylpiperidin-1-yl)-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-7-(4-ethyl-3-hydroxymethylpiperidin-1-yl)-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-7-(4-ethyl-3-hydroxypiperidin-1-yl)-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-7-[3-(1,2-dihydroxy-2-methylpropyl)-4-fluoropyrrolidin-1-yl]-6-fluoro-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-7-[3-fluoro-4-(3,3,3-trifluoro-1,2-dihydroxy-2-trifluoromethylpropyl)pyrrolidin-1-yl]-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-7-{3-fluoro-4-[hydroxy-(1-hydroxycyclopropyl)methyl]pyrrolidin-1-yl}-8-methoxy-1H-quinazoline-2,4-dione;
• 1-Cyclopropyl-5-difluoromethyl-6-fluoro-7-{3-fluoro-4-[hydroxy-(1-hydroxycyclopentyl)methyl]pyrrolidin-1-yl}-8-methoxy-1H-quinazoline-2,4-dione;
• or
• a pharmaceutically acceptable salt thereof.

A process for preparing a compound of formula IX, wherein R1, R2, R3, R4, R6, J, K, Z, Z′, z, and R′ are as defined above and R5′ is halo, comprising:

• (a) coupling compound IXA wherein R5 is halo with compound IXB wherein M is n-Bu3Sn in the presence of Pd° to provide the R5-coupled product IXC;
• 451
• and
• (b) removing the R′ group in IXC to provide compound IXD
• 452