Antibacterial substituted 7-acylamino-3-(methylhydrazono) methyl-cephalosporins and intermediates
OwnerGerd Ascher, Josef Wieser +3inventors
InventorsGerd Ascher, Josef Wieser, Michael Schranz, Johannes Ludescher, Johannes Hildebrandt
Life of this patent
Estimating the term…
Abstract
A compound of formula 1 wherein W, V, R1, R5, R2, R3 and R4 have various meanings, a process for their production and their use as a pharmaceutical.
Claims15
A compound of formula
- 55
- wherein
- R1 denotes hydrogen, acyl, carboxyl, or alkyl;
- R2 and R3 are the same or different and independently of each other denote hydrogen, cycloalkyl, alkyl, alkenyl or alkinyl;
- R4 denotes hydrogen or a group of formula
- 56
- wherein R6 denotes amino, hydrazino aminoalkylamino, alkoxy, aryl, cycloalkyl, aryloxy, heterocyclyl, alkyl, alkenyl, alkinyl;
- Z denotes O, S or NR7, wherein R7 is as defined as R2;
- R5 denotes hydrogen or an ester moiety;
- W denotes CH or N;
- V denotes CH or N—O;
- with the proviso that not all of R2, R3 and R4 denote hydrogen;
- and
- if R4 denotes hydrogen, R1 is other than h or CH3.
A compound of any preceding claim in the form of a salt and/or in the form of a solvate.
7-(((5-Amino-1,2,4-thiadiazol-3-yl)-(Z)-(fluormethoxyimino)acetyl)amino)-3(E)-((imino-1-piperazinylmethyl)methylhydrazono)methyl-3-cephem-4-carboxylic acid in the form of a hydrochloride.
7-(((5-Amino-1,2,4-thiadiazol-3-yl)-(Z)-(fluormethoxyimino)acetyl)amino)-3(E)-((imino-1-piperazinylmethyl)methylhydrazono)methyl-3-cephem-4-carboxylic acid in the form of a trihydrochloride.
A compound selected from
- 1-[(1-Methylhydrazino)iminomethyl]piperazine
- 1-[(1-Ethylhydrazino)iminomethyl]piperazine
- 1-[(1-Allylhydrazino)iminomethyl]piperazine
- 1-[(1-(4-Methoxybenzyl)hydrazino]iminomethyl]piperazine
- 1-[(1-(3,4,5-Trimethoxybenzyl)hydrazino]iminomethyl]piperazine
- 1-[(1-Methylhydrazino)(methylimino)methyl]piperazine
- 1-[(1-Methylhydrazino)(ethylimino)methyl]piperazine
- Glycin-(4-hydrazinoiminomethyl)piperazide
- 1-(R)-(Amino(4-hydroxyphenyl)acetyl)4-(hydrazinoiminomethyl)piperazine
- 1,4-bis-(Hydrazinoiminomethyl)piperazine, or
- 1-(Hydrazinoiminomethyl)4-[ethylimino) [3-dimethylaminopropyl)amino]methyl]-piperazine.
A method of treatment of microbial diseases which comprises administering to a subject in need of such treatment an effective amount of a compound of formula I.
Dependencies are inferred from the claim text.