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AssigneeShearwater Corporation
InventorsJ. Milton Harris, Francesco Maria Veronese, Paolo Caliceti, Oddone Schiavon
Estimating the term…
Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure 1 wherein Z is a moiety that can be activated for attachment to biologically active molecules such as proteins and wherein P and Q represent linkage fragments that join polymer arms polya and polyb, respectively, to central carbon atom, C, by hydrolytically stable linkages in the absence of aromatic rings in the linkage fragments. R typically is hydrogen or methyl, but can be a linkage fragment that includes another polymer arm. A specific example is an mPEG disubstituted lysine having the structure 2 where mPEGa and mPEGb have the structure CH3O—(CH2CH2O)nCH2CH2— wherein n may be the same or different for polya- and polyb- and can be from 1 to about 1,150 to provide molecular weights of from about 100 to 100,000.
A polymeric derivative represented by the structure
A polymeric derivative represented by the structure
A multi-armed monofunctional polymeric derivative that is the reaction product of at least one monofunctional nonpeptidic polymer derivative and a linker moiety having two or more active sites that form linkages with said monofunctional nonpeptidic polymer derivatives in the absence of aromatic moieties, wherein said linkages between said linker moiety and said monofunctional nonpeptidic polymer derivatives are hydrolytically stable.
A two-armed polymeric derivative having a structure selected from the group consisting of:
A molecule having the structure
A method of synthesizing a multi-armed, water soluble, monofunctional polymeric molecule comprising reacting one or more nonpeptidic monofunctional polymers of the structure poly-W, wherein W is an active moiety providing the monofunctionality for the polymer, with a linker moiety having two or more active sites with which W is reactive, and forming hydrolytically stable linkages in the absence of aromatic rings between the monofunctional polymer and the linker moiety at the linker moiety active sites, the linker moiety having a reactive site for which said active moiety —W is not reactive to provide the monofunctionality for the multi-armed molecule.
A method for preparing a polymeric derivative represented by the structure
A method for forming monofunctional monomethoxy-poly(ethylene glycol) disubstituted lysene comprising the following step:
A method for forming a monofunctional monomethoxy-poly(ethylene glycol) disubstituted compound comprising the following steps:
Dependencies are inferred from the claim text.