Regulation of human serotonin-like g protein-coupled receptor
OwnerShyam Ramakrishnaninventor
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Abstract
Reagents which regulate human serotonin-like G protein-coupled receptor (5-HT-GPCR) and reagents which bind to human 5-HT-GPCR gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to disorders of both the central and the peripheral nervous system, for example in primary and secondary disorders after brain injury, disorders of mood, anxiety disorders, disorders of thought and volition, disorders of sleep and wakefulness, diseases of the motor unit like neurogenic and myopathic disorders, neurodegenerative disorders like Alzheimer's and Parkinson's disease, disorders leading to peripheral and chronic pain.
Claims18
An isolated polynucleotide encoding a 5-HT-GPCR polypeptide and being selected from the group consisting of:
- a) a polynucleotide encoding a 5-HT-GPCR polypeptide comprising an amino acid sequence selected from the group consisting of:
- amino acid sequences which are at least about 50% identical to the amino acid sequence shown in SEQ ID NO:
- 2;
- and
- the amino acid sequence shown in SEQ ID NO:
- 2.
- b) a polynucleotide comprising the sequence of SEQ ID NO:
- 1;
- c) a polynucleotide which hybridizes under stringent conditions to a polynucleotide specified in (a) and (b);
- d) a polynucleotide the sequence of which deviates from the polynucleotide sequences specified in (a) to (c) due to the degeneration of the genetic code;
- and
- e) a polynucleotide which represents a fragment, derivative or allelic variation of a polynucleotide sequence specified in (a) to (d).
Dependencies are inferred from the claim text.