Poly(L-lactide-co-glycolide) copolymers, methods for making and using same, and devices containing same
AssigneeSynthes USA, LLC
InventorSylwester Gogolewski
Life of this patent
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Abstract
The present invention relates in general to implantable, resorbable copolymers containing L-lactide and glycolide repeat units, and in particular to terpolymers containing L-lactide, glycolide, and one other type of repeat unit selected from the group consisting of D-lactide, D,L-lactide, and ε-caprolactone. Medical devices for in vivo implantation applications containing such implantable, resorbable copolymers are also described, as well as methods for making such copolymers and devices.
Claims42
An implantable medical device comprising a terpolymer having repeat units of L-lactide, D-lactide, and glycolide.
An implantable medical device comprising a terpolymer having repeat units of L-lactide, D,L-lactide, and glycolide.
An implantable medical device comprising a terpolymer having repeat units of L-lactide, ε-caprolactone, and glycolide.
An implantable medical device comprising a terpolymer having repeat units depicted by the following formula:
- 3
- wherein the repeat unit having subscript x is an L-lactide repeat unit, the third component having subscript y is a D-lactide repeat unit;
- the molar percentages of the repeating units are such that x is from about 0.75 to about 0.9, y is from about 0.02 to about 0.16, and z is from about 0.04 to about 0.18;
- and x+y+z=1.
A terpolymer comprising form about 75% to about 90% L-lactide repeat units, from about 4% to about 11% D-lactide repeat units, and from about 4% to about 18% glycolide repeat units.
A terpolymer comprising at least about 50% L-lactide repeat units, from about 1% to about 20% repeat units from ε-caprolactone, and from about 1% to about 30% glycolide repeat units.
A terpolymer comprising at least about 50% L-lactide repeat units, from about 1% to about 20% D,L-lactide repeat units, and from about 1% to about 30% glycolide repeat units.
Dependencies are inferred from the claim text.