Method of treating autoimmune diseases
AssigneeWake Forest University
InventorsGary M. Kammer, Nilamadhab Mishra
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Abstract
A method of treating an autoimmune disease comprising administering to the subject a treatment effective amount of a histone hyperacetylating agent, or a pharmaceutically acceptable salt thereof.
Claims36
A method of treating an autoimmune disease in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of a histone hyperacetylating agent, or a pharmaceutically acceptable salt thereof.
A method of treating systemic lupus erythematosus in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of a histone hyperacetylating agent, or a pharmaceutically acceptable salt thereof.
A method of treating an autoimmune disease in a subject in need thereof, the method comprising administering to a subject a histone hyperacetylating agent in an amount effective to treat the disease, wherein the agent binds to a histone in vivo.
A method of treating an autoimmune disease in a subject in need thereof, the method comprising administering to the subject a pharmaceutical formulation comprising a pharmaceutically acceptable carrier and a compound selected from the group consisting of a trichostatin, butyrate, trapozin, isoquinolin, depsipeptide and hydroxamic acid or a pharmaceutically acceptable salt thereof, in an amount sufficient to treat a symptom of autoimmune disease.
A method of treating an autoimmune disease in a subject in need thereof, comprising administering a compound of the general formula (I)
- 2
- wherein each of R1 and R2 is, substituted or unsubstituted, hydrogen, aryl, cycloalkyl, cycloalkylamino, naphtha, pyridineamino, piperidino, t-butyl, aryloxy, arylalkoyloxy, phenyl or pyridine group;
- and wherein n is an integer from 3 to 8;
- or a pharmaceutical acceptable salt thereof, in an amount sufficient to treat a symptom of an autoimmune disease.
A method of treating lupus in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of a histone deacetylase inhibitor, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.