Compounds with hydroxycarbonyl-halogenoalkyl side chain

A compound consisting of a moiety and a group chemically bonded to said moiety, wherein said moiety contains a compound having anti-tumor activity or its parent scaffold and said group has the following general formula (1):

• 162
• in which
• R1 represents a hydrogen atom or a salt-forming metal,
• R2 represents a linear or branched C1-C7 halogenoalkyl group,
• m represents an integer of 2 to 14, and
• n represents an integer of 2 to 7,
• or enantiomers of the first-mentioned compound, or hydrates or pharmaceutically acceptable salts of the first-mentioned compound or enantiomers thereof.

A compound consisting of a moiety and a group chemically bonded to said moiety, wherein said moiety contains an estrogenic compound or its parent scaffold or an anti-estrogenic compound or its parent scaffold and said group has the following general formula (1):

• 163
• in which
• R1 represents a hydrogen atom or a salt-forming metal,
• R2 represents a linear or branched C1-C7 halogenoalkyl group,
• m represents an integer of 2 to 14, and
• n represents an integer of 2 to 7,
• or enantiomers of the first-mentioned compound, or hydrates or pharmaceutically acceptable salts of the first-mentioned compound or enantiomers thereof.

A compound having the following general formula (2):

• 164
• in which
• R1 represents a hydrogen atom or a salt-forming metal,
• R2 represents a linear or branched C1-C7 halogenoalkyl group,
• m represents an integer of 2 to 14,
• n represents an integer of 2 to 7, and
• A represents a group selected from the following formulae (3) to (8) and (10) to (26):
• 165
• in which
• in formulae (6), (7), (14) and (24), each of R3 and R6 represents a linear or branched C1-C5 alkyl group,
• in formulae (10), (11) and (12), Z10 represents a hydrogen atom or an acyl group,
• in formulae (13), (21) and (22), each of Z1, Z2, Z3, Z4, Z5 and Z6 independently represents a hydrogen atom, a hydroxyl group or a linear or branched C1-C5 alkyl group,
• in formula (15), R7 represents a hydrogen atom or a linear or branched C1-C5 alkyl group,
• in formula (16), each of Z7, Z8 and Z9 independently represents a hydrogen atom or a hydroxyl group,
• in formulae (18) and (20), R8 represents a linear or branched C1-C5 alkyl group, a linear or branched C2-C5 alkenyl group or a linear or branched C2-C5 alkynyl group,
• in formula (23), each of R21, R22, R23 and R24 independently represents a hydrogen atom, a linear or branched C1-C5 alkyl group, a linear or branched C1-C7 halogenoalkyl group, a halogen atom or an acyl group, and
• in formulae (25) and (26), X represents a halogen atom,
• or enantiomers of the compound, or hydrates or pharmaceutically acceptable salts of the compound or enantiomers thereof.