Substituted urea neuropeptide Y Y5 receptor antagonists

A compound having the structural formula I:

• 462
• R1 is hydrogen or (C1-C6)alkyl;
• R2 is hydrogen, (C1-C6)alkyl, (C3-C9)cycloalkyl or (C3-C7)cycloalkyl(C1-C6)alkyl;
• 463
• where Z is OR10 or —N(R9)(R10);
• j is 0, 1 or 2;
• k is 1 or 2;
• l is 0, 1 or 2;
• m is 0, 1 or 2;
• p is 1, 2 or 3;
• r is 1, 2 or 3;
• and s is 0, 1,2,3,4, 5 or 6;
• R4 is a subsituent independently selected from hydrogen, —OH, halogen, haloalkyl, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkyl(C1-C6)alkyl, —CN, (C1-C6)alkylO-, (C3-C7)cycloalkylO-, (C1-C6)alkyl(C3-C7)cycloalkylO-, (C1-C6)alkylS-, (C3-C7)cycloalkylS-, (C1-C6)alkyl(C3-C7)cycloalkylS-, —NR9R10, —NO2, —CONR9R10 and —NR2COR10;
• R5 is a substituent independently selected from hydrogen, halogen, —OH, haloalkyl, haloalkoxy, —CN, —NO2, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkyl(C1-C6)alkyl, (C1-C6)alkylO-, (C3-C7)cycloalkylO-, (C1-C6)alkyl(C3-C7)cycloalkylO-, —CONH2 and —CONR9R10;
• R6 is (C1-C6)alkylSO2—, (C3-C7)cycloalkylSO2—, (C1-C6)alkyl(C3-C7)cycloalkylSO2—, (C1-C6)haloalkylSO2—, hydroxy(C2-C6)alkyl)SO2,-, (amino(C2-C6)alkyl)SO2—, alkoxy(C2-C6)alkyl)SO2—, alkylamino(C2-C6)alkyl)SO2—, dialkylamino(C2-C6)alkyl)SO2—, arylSO2—, heteroarylSO2—, aryl(C2-C6-alkylSO2—, R9R10NSO2—, (C1-C6)alkylC(O)—, (C3-C7)cycloalkylC(O)—, (C3-C7)cycloalkyl(C1-C6)alkylC(O)—, arylC(O)—, heteroarylC(O)—, R9R10NC(O)—, —(S)CNR9R10, aryl, heteroaryl, —(CH2)nC(O)NR9R10, alkylS(NCN═)C—, R9R1ON(NCN═)C—, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkyl(C1-C6)alkyl, aryl(C1-C6)alkyl, heteroaryl(C1-C6)alkyl, or R9OC(O)—;
• R7=hydrogen or alkyl;
• R8 is hydrogen, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkyl(C1-C6)alkyl, aryl, heteroaryl, (C1-C6)alkylSO2—, (C3-C7)cycloalkylSO2—, (C1-C6)alkyl(C3-C7)cycloalkylSO2—, (C1-C6)haloalkylSO2— or arylSO2—;
• R9 is hydrogen, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkyl(C1-C6)alkyl, aryl(C1-C6)alkyl, aryl, acyl or heteroaryl;
• and,
• R10 is hydrogen, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkyl(C1-C6)alkyl, aryl(C1-C6)alkyl, aryl or heteroaryl;
• or R9 and R10 taken together with the nitrogen atom form a 4-7 membered ring containing 1 or 2 heteroatoms selected from N, O or S with proviso that two O or S atoms are not adjacent to one another;
• n=1to 6;
• or a pharmaceutically acceptable salt and/or hydrate thereof.