Nitrogen heterocycle inhibitors of aspartyl protease

A compound of formula

• 49
• wherein
• R1 is chosen from the group consisting of C1-C20 alkyl, aryl, alkylaryl, substituted alkylaryl, C1-C10 alkoxy, C3-C10 oxaalkyl, aryloxy, substituted aryl, substituted aryloxy, heterocyclyl and heterocyclyloxy;
• R2 is chosen from the group consisting of C1-C10 hydrocarbon, substituted aryl and heterocyclyl;
• A is chosen from the group consisting of —SO2—, NHSO2—,
• 50
• 51
• is a monocyclic, bicyclic or tricyclic nitrogen heterocycle
• containing from 0
• to 3 substituents chosen from lower alkyl, lower alkoxy, lower alkylthio, hydroxy, mercapto, cyano, carboxy, lower alkoxycarbonyl, lower alkylaminocarbonyl, amino, lower alkylamino, di(lower alkyl)amino, nitro, halo and haloalkyl;
• R5, R6 and R7 are chosen independently from the group consisting of hydrogen and lower alkyl;
• D is chosen from the group consisting of —SO2—,
• 52
• E is chosen from the group consisting of C1-C10 hydrocarbon, substituted aryl, heterocyclyl and substituted heterocyclyl,
• and pharmaceutically acceptable salts thereof.