Anthranilamides with heteroarylsulfonyl side chain, process of preparation, and use

A compound of formula I

• 130
• in which R1 is:
• 131
• where A is —CnH2n— and n=0, 1, 2, 3, 4, or 5;
• D is a bond or —O—;
• E is —CmH2m— and m=0, 1, 2, 3, 4, or 5;
• R8 is hydrogen, alkyl having 1, 2, 3, or 4 carbon atoms, or CpH2p—R14 where p is 0, 1, 2, 3, 4, or 5 and where R14 is phenyl, naphthyl, or heteroaryl, where phenyl, naphthyl, or heteroaryl are unsubstituted or substituted by 1, 2, or 3 substituents selected from F, Cl, Br, I, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alkyl having 1, 2, 3, or 4 carbon atoms, alkoxy having 1, 2, 3, or 4 carbon atoms, dimethylamino, sulfamoyl, methylsulfonyl, and methylsulfonylamino;
• R9 is hydrogen or alkyl having 1, 2, 3, 4, 5, or 6 carbon atoms;
• R10 is hydrogen, alkyl having 1, 2, 3, or 4 carbon atoms, phenyl, naphthyl or heteroaryl, where phenyl, naphthyl, or heteroaryl are unsubstituted or substituted by 1, 2, or 3 substituents selected from F, Cl, Br, I, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alkyl having 1, 2, 3, or 4 carbon atoms, alkoxy having 1, 2, 3, or 4 carbon atoms, dimethylamino, sulfamoyl, methylsulfonyl, and methylsulfonylamino;
• R11 is cycloalkyl having 3, 4, 5, or 6 carbon atoms, phenyl, naphthyl, thienyl, furyl, pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolyl, indazolyl, quinolyl, isoquinolyl, phthalazinyl, quinoxalinyl, quinazolinyl or cinnolinyl, where phenyl, naphthyl, thienyl, furyl, pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolyl, indazolyl, quinolyl, isoquinolyl, phthalazinyl, quinoxalinyl, quinazolinyl, or cinnolinyl are unsubstituted or substituted by 1, 2, or 3 substituents selected from F, Cl, Br, I, CF3, OCF3, NO2, CN, COMe, NH2, OH, alkyl having 1, 2, 3, or 4 carbon atoms, alkoxy having 1, 2, 3, or 4 carbon atoms, dimethylamino, sulfamoyl, methylsulfonyl, and methylsulfonylamino;
• R12 is alkyl having 1, 2, 3, or 4 carbon atoms, alkynyl having 1, 2, 3, or 4 carbon atoms, cycloalkyl having 3, 4, 5, or 6 carbon atoms, phenyl, naphthyl or heteroaryl where phenyl, naphthyl, or heteroaryl are unsubstituted or substituted by 1, 2, or 3 substituents selected from F, Cl, Br, I, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alkyl having 1, 2, 3, or 4 carbon atoms, alkoxy having 1, 2, 3, or 4 carbon atoms, dimethylamino, sulfamoyl, methylsulfonyl, and methylsulfonylamino;
• R13 is CpH2p—R14;
• R15 is cycloalkyl having 3, 4, 5, 6, 7, or 8 carbon atoms;
• R2 is hydrogen or alkyl having 1, 2, 3, or 4 carbon atoms;
• R3 is heteroaryl, where heteroaryl is unsubstituted or substituted by 1, 2, or 3 substituents selected from F, Cl, Br, I, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alkyl having 1, 2, 3, or 4 carbon atoms, alkoxy having 1, 2, 3, or 4 carbon atoms, dimethylamino, sulfamoyl, methylsulfonyl, and methylsulfonylamino;
• R4, R5, R6, and R7 are, independently of one another, hydrogen, F, Cl, Br, I, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alkyl having 1, 2, 3, or 4 carbon atoms, alkoxy having 1, 2, 3, or 4 carbon atoms, dimethylamino, sulfamoyl, methylsulfonyl, or methylsulfonylamino;
• and the pharmaceutically acceptable salts thereof.