Novel cyclohexyl sulphones

A compound of formula I:

• 114
• wherein:
• m is 0 or 1;
• Z represents halogen, CN, NO2, N3, CF3, OR2a, N(R2a)2, CO2R2a, OCOR2a, COR2a, CON(R2a)2, OCON(R2a)2, CONR2a(OR2a), CON(R2a)N(R2a)2CONHC(═NOH)R2a, heterocyclyl, phenyl or heteroaryl, said heterocyclyl, phenyl or heteroaryl bearing 0-3 substituents selected from halogen, CN, NO2, CF3, OR2a, N(R2a)2, CO2R2a, COR2a, CON(R2a)2 and C1-4alkyl;
• R1b represents H, C1-4alkyl or OH;
• R1c represents H or C1-4alkyl;
• with the proviso that when m is 1, R1b and R1c do not both represent C1-4alkyl;
• Ar1 represents C6-10aryl or heteroaryl, either of which bears 0-3 substituents independently selected from halogen, CN, NO2, CF3, OH, OCF3, C1-4alkoxy or C1-4alkyl which optionally bears a substituent selected from halogen, CN, NO2, CF3, OH and C1-4alkoxy;
• Ar2 represents C6-10aryl or heteroaryl, either of which bears 0-3 substituents independently selected from halogen, CN, NO2, CF3, OH, OCF3, C1-4alkoxy or C1-4alkyl which optionally bears a substituent selected from halogen, CN, NO2, CF3, OH and C1-4alkoxy;
• R2a represents H, C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkylC1-6alkyl, C2-6alkenyl, any of which optionally bears a substituent selected from halogen, CN, NO2, CF3, OR2b, CO2R2b, N(R2b)2, CON(R2b)2, Ar and COAr;
• or R2a represents Ar;
• or two R2a groups together with a nitrogen atom to which they are mutually attached may complete an N-heterocyclyl group bearing 0-4 substituents independently selected from ═O, ═S, halogen, C1-4alkyl, CN, NO2, CF3, OH, C1-4alkoxy, C1-4alkoxycarbonyl, CO2H, amino, C1-4alkylamino, di(C1-4alkyl)amino, carbamoyl, Ar and COAr;
• R2b represents H, C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkylC1-6alkyl, C2-6alkenyl, any of which optionally bears a substituent selected from halogen, CN, NO2, CF3, OH, C1-4alkoxy, C1-4alkoxycarbonyl, CO2H, amino, C1-4alkylamino, di(C1-4alkyl)amino, carbamoyl, Ar and COAr;
• or R2b represents Ar;
• or two R2b groups together with a nitrogen atom to which they are mutually attached may complete an N-heterocyclyl group bearing 0-4 substituents independently selected from ═O, ═S, halogen, C1-4alkyl, CN, NO2, CF3, OH, C1-4alkoxy, C1-4alkoxycarbonyl, CO2H, amino, C1-4alkylamino, di(C1-4alkyl)amino, carbamoyl, Ar and COAr;
• Ar represents phenyl or heteroaryl bearing 0-3 substituents selected from halogen, C1-4alkyl, CN, NO2, CF3, OH, C1-4alkoxy, C1-4alkoxycarbonyl, amino, C1-4alkylamino, di(C1-4alkyl)amino, carbamoyl, C1-4alkylcarbamoyl and di(C1-4alkyl)carbamoyl;
• “heterocyclyl” at every occurrence thereof means a cyclic or polycyclic system of up to 10 ring atoms selected from C, N, O and S, wherein none of the constituent rings is aromatic and wherein at least one ring atom is other than C;
• and
• “heteroaryl” at every occurrence thereof means a cyclic or polycyclic system of up to 10 ring atoms selected from C, N, O and S, wherein at least one of the constituent rings is aromatic and wherein at least one ring atom of said aromatic ring is other than C;
• or a pharmaceutically acceptable salt thereof.