New processes for producing beta-alanine derivatives
AssigneeFujisawa Pharmaceutical Co., Ltd.
InventorsMitsuru Ohkubo, Satoru Kuroda, Hideko Nakamura, Hisashi Takasugi, Yosuke Fujii, Keiichi Koga, Eiki Oikawa, Ryoki Orii, Shunsuke Goto
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Abstract
The present invention relates to processes for the preparation of β-alanine derivative shown by following formula (I): 1 wherein R1 is amino protective group, and R2 is acyl group, or a salt thereof, which comprises, subjecting a compound of the formula (II): 2 wherein R1 is the same as defined above, and R3 is protected carboxy, or a salt, to elimination reaction of carboxy protective group, and then to acylation reaction of amino group.
Claims6
A process for preparing a compound of the formula (I):
- 4
- wherein R1 is amino protective group, and
- R2 is acyl group, or a salt thereof, which comprises, subjecting a compound of the formula (II):
- 5
- wherein R1 is the same as defined above, and
- R3 is protected carboxy, or a salt thereof, to elimination reaction of carboxy protective group, and then to acylation reaction of amino group.
N-[(R)-1-[3-(4-piperidyl)propionyl]-3-piperidyl-carbonyl]-2(S)-acetylamino-β-alanine trihydrate.
Dependencies are inferred from the claim text.