Anellated dihydropyridines for the treatment of chronic pain
AssigneeBoehringer Ingelheim Pharma GmbH & Co. KG
InventorsDietrich Arndts, Walter Loesel, Wolfram Gaida, Klaus Klinder, Stefan Matthias Blech, Henning Draheim
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Abstract
The invention relates to the use of anellated dihydropyridines according to the following formula I, and the salts thereof with physiologically acceptable acids, for the treatment of chronic pain, wherein A is benzo or thieno and Z, R1, R2, R3, R4, R5 and R6 are defined as in the specification: 1 The inventions also relates to novel compounds of formula I and pharmaceutical compositions thereof.
Claims23
1) A method of treating chronic pain comprising administering to a host in need of such treatment a compound of the following formula I or a salt thereof with a physiologically acceptable acid:
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- wherein A is benzo or thieno,
- and if A is benzo
- R1, R2 and R3 independently of one another denote
- H, OH,C1-C5 alkyl, C1-C5 alkoxy, or —O—(CH2)1-5—OCH3,
- or R2 and R3 together form the group
- —O—CH2—O—, and
- if A is thieno, R1, R2 and R3 denote hydrogen;
- R4 and R5 independently of one another denote
- H, or C1-C5 alkyl or together with the atom to which they are bonded form a C3-C7 ring;
- R6 denotes C1-C12 alkyl, or denotes a phenyl or benzyl group each substituted by the groups R7and R8,
- wherein R7 and R8 independently of one another denote hydrogen, halogen, C1-C5 alkyl, C1-C5 alkoxy or C1-C5 fluoroalkyl group;
- Z denotes O, S or an NHCO— group or, if at least one of the groups R4 and R5 is other than hydrogen, Z may also denote a single bond.
Dependencies are inferred from the claim text.